Evidence map›Paper›PMID 38853647›Full record

ReviewExpert opinion on pharmacotherapy2024

The effects of prenatal exposure to opioids on early childhood development: context matters most.

Ginny Carter, Sarah McGlothlin, Skye McLaurin-Jiang, Rebecca B Carlson, Kevin E O'Grady, Hendree E Jones

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert opinion on pharmacotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ginny CarterUNC Horizons, University of North Carolina at Chapel Hill, Carrboro, NC, USA.
Sarah McGlothlinSchool of Social Work, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Skye McLaurin-JiangJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Rebecca B CarlsonHealth Sciences Library, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kevin E O'GradyDepartment of Psychology, University of Maryland College Park, College Park, MD, USA.
Hendree E JonesUNC Horizons, University of North Carolina at Chapel Hill, Carrboro, NC, USA.

Funding

Medically-supervised withdrawal vs. agonist maintenance in the treatment of pregnant women with opioid use disorder: Maternal, fetal, and neonatal outcomesR01DA047867 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HEIL, SARAH H, JONES, HENDREE E · 2018 to 2022
$3.3M
NIDA NIH HHS R01 DA047867
6 · The paper itself

Abstract

introductionThe opioid crisis has brought an increasing focus on the long-term outcomes of children following prenatal opioid exposure. Evidence to date has been conflicting, which has caused confusion and concern amongst parents, caregivers, social service providers, medical providers and policy makers.

methodsThis review systematically evaluated the highest quality studies relating prenatal exposure to opioids with early childhood developmental outcomes. It focused on developmental outcomes as measured by the Bayley Scales of Infant and Toddler Development, encompassing cognitive, motor, and psychosocial domains of child development.

resultsAlthough several articles reported correlations between prenatal opioid exposure and poor early childhood developmental outcomes, these relationships were no longer statistically significant after adjusting for socio-environmental factors.

conclusionAdditional research is needed to determine the extent of any relationship of socio-environmental factors with early childhood development in children prenatally exposed to opioids. This review suggests that socio-environmental factors may be significantly related to poor early childhood outcomes in the presence of prenatal opioid exposure.

Indexed as

Analgesics, OpioidChild DevelopmentPrenatal Exposure Delayed EffectsChild, PreschoolFemaleHumansInfantPregnancyAnalgesics, OpioidBayley scales of infant and toddler developmentmaternal opioid useprenatal opioid exposuresocio-environmental factors in child development

Identifiers

PMID38853647
PMCPMC11490307

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.