ArticleBJOG : an international journal of obstetrics and gynaecology2024
Polybrominated diphenyl ethers and gestational weight gain: a multi-center prospective cohort study.
Zifan Wang, Paige L Williams, Andrea Bellavia, Blair J Wylie, Kurunthachalam Kannan, Michael S Bloom, Kelly J Hunt, Michele R Hacker, Cuilin Zhang, Tamarra James-Todd
Article in BJOG : an international journal of obstetrics and gynaecology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Kelly J HuntDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Michele R HackerDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Cuilin ZhangGlobal Centre for Asian Women's Health, Bia-Echo Asia Centre for Reproductive Longevity and Equality (ACRLE), NUS Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Tamarra James-ToddDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Funding
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Exposome Contributors to Child Health Originating from National Fetal Growth Study (ECCHO-NFGS)UG3OD023316 · OD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HUNT, KELLY J, WAPNER, RONALD · 2016 to 2017
$10.8M
A South Carolina ECHO Pregnancy CohortUH3OD035543 · OD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KELLY J HUNT, ROGER B NEWMAN · 2025 to 2026
$5.0M
Maternal organophosphate pesticide exposure, low birth weight and placental injuryR01ES028688 · NIEHS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HACKER, MICHELE RENEE, WYLIE, BLAIR JOHNSON · 2018 to 2021
$2.1M
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HHSN27500006Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HHSN275200800003ICEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HHSN275291199991INICHD NIH HHS HHSN275200800002CNICHD NIH HHS HHSN275200800002INICHD NIH HHS HHSN275200800003CNICHD NIH HHS HHSN275200800003INICHD NIH HHS HHSN275200800012CNICHD NIH HHS HHSN275200800013CNICHD NIH HHS HHSN275200800014CNICHD NIH HHS HHSN275200800028CNICHD NIH HHS HHSN275201000001GNICHD NIH HHS HHSN275201000001ZNICHD NIH HHS HHSN275201000009CNIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30ES000002NIEHS NIH HHS R01 ES028688NIH HHS UG3 OD023316NIH HHS UG3OD023316NIH HHS UH3 OD035543
6 · The paper itself
Abstract
objectiveTo evaluate the associations of plasma polybrominated diphenyl ether (PBDE) concentrations in early pregnancy with gestational weight gain (GWG).
designProspective cohort study.
settingUS-based, multicentre cohort of pregnant women. POPULATION: We used data from 2052 women without obesity and 397 women with obesity participating in the NICHD Fetal Growth Studies - Singleton Cohort, with first-trimester plasma PBDE concentrations and weight measurements throughout pregnancy.
methodsWe applied generalised linear models and Bayesian kernel machine regression (BKMR) to evaluate both the individual and joint associations of PBDEs with measures of GWG, adjusting for potential confounders.
main outcome measuresTotal GWG (kg), total and trimester-specific GWG velocities (kg/week), and GWG categories and trajectory groups.
resultsMean pre-pregnancy BMIs were 23.6 and 34.5 kg/m
conclusionsPBDEs were not associated with GWG among individuals without obesity. Among those with obesity, only PBDE 47 showed consistent positive associations with GWG measures across multiple statistical methods. Further research is needed to validate this association and explore potential mechanisms.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
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