ArticleBMC medicine2024
Examining the impact of substance use on hospital length of stay in schizophrenia spectrum disorder: a retrospective analysis.
Article in BMC medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Clinical Utility of Cariprazine in the Management of Acute Schizophrenia: Current Evidence and Practical Recommendations.Actas espanolas de psiquiatria · 2026Review
- Brexpiprazole vs. Aripiprazole in Patients with Schizophrenia with or Without Comorbid Substance Use Disorder: A 12-Month Real-World Naturalistic Study of Efficacy.Brain sciences · 2026Article
- Beyond the Bed: What Clinical and Non-clinical Factors Drive Length of Stay in Pediatric Psychiatry?Clinical child psychology and psychiatry · 2026Article
- Profile of male acute admissions at a state psychiatric hospital in the Western Cape, South Africa.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2026Article
- Substance abuse in first-episode psychosis at Chris Hani Baragwanath Hospital.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2026Article
- Clinical symptoms and risk factors in people with mental disorders: findings from the interRAI emergency screener for psychiatry in Brazil.Frontiers in psychiatry · 2026Article
- ADHD and schizophrenia: Mere prodromal variant or homogeneous subgroup?Schizophrenia research. Cognition · 2025Article
- Crisis versus extended care: bimodal distribution of length of stay in psychiatric inpatients.BMC psychiatry · 2025Article
- Determinants of compulsory admission in detainees with acute psychiatric symptoms in the French speaking counties of Switzerland.BMC psychiatry · 2025Article
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Authors and funding
7 authors.
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Abstract
backgroundAmong patients diagnosed with schizophrenia, the presence of substance use poses an aggravating comorbidity, exerting a negative impact on the course of the disease, adherence to therapeutic regimens, treatment outcomes, duration of hospital stays, and the frequency of hospitalizations. The primary objective of the present study is to investigate the relationship between comorbid substance use disorders, antipsychotic treatment, and the length of stay in individuals hospitalized for treatment of schizophrenia.
methodsWe conducted a retrospective analysis of electronic health records spanning a 12-month period, specifically focusing on adult patients diagnosed with schizophrenia who were discharged from the University Hospital of Psychiatry Zurich between January and December 2019. We documented the number and types of diagnosed substance use disorder, the antipsychotic treatment, the length of stay, and the number of previous hospitalizations for each patient.
resultsOver a third (n = 328; 37.1%) of patients with schizophrenia had comorbid substance use with cannabis being the most frequent consumed substance. Patients with substance use (either single or multiple) were more frequently hospitalized; those with multiple substance use more frequently than those with a single substance use (F(2, 882) = 69.06; p < 0.001). There were no differences regarding the rate of compulsory admission. Patients with no substance use had a lower HoNOS score at discharge (F(2, 882) = 4.06). Patients with multiple substance use had a shorter length of stay (F(2, 882) = 9.22; p < 0.001), even after adjusting for duration of illness, previous hospitalizations, diagnosis, and antipsychotic treatment.
conclusionsIn patients with schizophrenia, comorbid single or multiple substance use has a relevant negative impact on treatment and thus on the course of disease. Substance use in patients with schizophrenia should therefore receive special attention in order to reduce re-hospitalization rates and improve the clinical outcome.
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