ArticleBMC medicine2024
How do lifestyle factors modify the association between genetic predisposition and obesity-related phenotypes? A 4-way decomposition analysis using UK Biobank.
Article in BMC medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Effects of obesity on brain health and cognition.Nature reviews. Neurology · 2026Review
- Genetic risk, antiseizure medications, and lifestyle factors in epilepsy-associated obesity and overweight.International journal of obesity (2005) · 2026Article
- Article
- Effects of the Uncoupling Protein 1 (UCP1) A-3826G Polymorphism on Taste Preferences in Healthy Young Japanese Adults.Life (Basel, Switzerland) · 2026Article
- Quality and reliability of weight management short videos on TikTok and Bilibili: cross-sectional study.Scientific reports · 2026Article
- Transcriptomics, lifestyle, and autoimmune thyroiditis: an integrated association study.Frontiers in immunology · 2026Article
- Combined in-person and home-based circuit exercise improves body composition and hormonal profiles in patients with post-bariatric weight regain: a genotype-stratified single-arm interventional study.Annals of surgical treatment and research · 2026Article
- Impact of Endodontic Treatment on CRP Levels in Apical Periodontitis: A Prospective Observational Cohort Study.Journal of clinical medicine · 2025Article
- Modifiable lifestyle factors and genetic risk of obesity in Indians.Scientific reports · 2025Article
- The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Genetic and environmental influences on educational disparities in adult weight change: an individual-based pooled analysis of 11 twin cohorts.medRxiv : the preprint server for health sciences · 2025Article
- Genetic Variants in Metabolic Pathways and Their Role in Cardiometabolic Risk: An Observational Study of >4000 Individuals.Biomedicines · 2025Article
- Influence of lifestyle risk factors and genetic predisposition on metabolic syndrome risk in Korean adults.Scientific reports · 2025Article
- Genetic predisposition to adiposity, and type 2 diabetes: the role of lifestyle and phenotypic adiposity.European journal of endocrinology · 2025Article
- Overweight in mediating the association between depression and new-onset diabetes: A population-based research from Health and Retirement Study.World journal of diabetes · 2025Article
- Obesity Defining Criteria, and Association with Cardiovascular Disease Risk Factors Among People Living with HIV in Jos, Nigeria.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
- Feasibility of Creating a Teaching and Learning Kitchen for an Interdisciplinary Group of Medical Professional Students While Creating a Bridge With an Inner-City Miami Community.Global advances in integrative medicine and healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity and central obesity are multifactorial conditions with genetic and non-genetic (lifestyle and environmental) contributions. There is incomplete understanding of whether lifestyle modifies the translation from respective genetic risks into phenotypic obesity and central obesity, and to what extent genetic predisposition to obesity and central obesity is mediated via lifestyle factors.
methodsThis is a cross-sectional study of 201,466 (out of approximately 502,000) European participants from UK Biobank and tested for interactions and mediation role of lifestyle factors (diet quality; physical activity levels; total energy intake; sleep duration, and smoking and alcohol intake) between genetic risk for obesity and central obesity. BMI-PRS and WHR-PRS are exposures and obesity and central obesity are outcomes.
resultsOverall, 42.8% of the association between genetic predisposition to obesity and phenotypic obesity was explained by lifestyle: 0.9% by mediation and 41.9% by effect modification. A significant difference between men and women was found in central obesity; the figures were 42.1% (association explained by lifestyle), 1.4% (by mediation), and 40.7% (by modification) in women and 69.6% (association explained by lifestyle), 3.0% (by mediation), and 66.6% (by modification) in men.
conclusionsA substantial proportion of the association between genetic predisposition to obesity/central obesity and phenotypic obesity/central obesity was explained by lifestyles. Future studies with repeated measures of obesity and lifestyle would be needed to clarify causation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.