Evidence map›Paper›PMID 38853201›Full record

ArticleApoptosis : an international journal on programmed cell death2024

The landscape of programmed cell death-related lncRNAs in Alzheimer's disease and Parkinson's disease.

Ning Zhao, Junyi Wang, Shan Huang, Jingyu Zhang, Jin Bao, Haisen Ni, Xinhang Gao, Chunlong Zhang

Abstract read
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In one paragraph

Article in Apoptosis : an international journal on programmed cell death, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Death never dies: increasing impact of programmed cell death.Apoptosis : an international journal on programmed cell death · 2025
    Article
  5. Article
  6. A cellular danse macabre: the choreography of programmed cell death.Apoptosis : an international journal on programmed cell death · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ning ZhaoCollege of Computer and Control Engineering, Northeast Forestry University, Harbin, Heilongjiang, China.
Junyi WangCollege of Computer and Control Engineering, Northeast Forestry University, Harbin, Heilongjiang, China.
Shan HuangThe Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
Jingyu ZhangThe Fourth Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
Jin BaoCollege of Computer and Control Engineering, Northeast Forestry University, Harbin, Heilongjiang, China.
Haisen NiCollege of Computer and Control Engineering, Northeast Forestry University, Harbin, Heilongjiang, China.
Xinhang GaoCollege of Computer and Control Engineering, Northeast Forestry University, Harbin, Heilongjiang, China.
Chunlong ZhangCollege of Computer and Control Engineering, Northeast Forestry University, Harbin, Heilongjiang, China. zhangcl@nefu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study delivers a thorough analysis of long non-coding RNAs (lncRNAs) in regulating programmed cell death (PCD), vital for neurodegenerative diseases like Alzheimer's disease (AD) and Parkinson's disease (PD). We propose a new framework PCDLnc, and identified 20 significant lncRNAs, including HEIH, SNHG15, and SNHG5, associated with PCD gene sets, which were known for roles in proliferation and apoptosis in neurodegenerative diseases. By using GREAT software, we identified regulatory functions of top lncRNAs in different neurodegenerative diseases. Moreover, lncRNAs cis-regulated mRNAs linked to neurodegeneration, including JAK2, AKT1, EGFR, CDC42, SNCA, and ADIPOQ, highlighting their therapeutic potential in neurodegenerative diseases. A further exploration into the differential expression of mRNA identified by PCDLnc revealed a role in apoptosis, ferroptosis and autophagy. Additionally, protein-protein interaction (PPI) network analysis exposed abnormal interactions among key genes, despite their consistent expression levels between disease and normal samples. The randomforest model effectively distinguished between disease samples, indicating a high level of accuracy. Shared gene subsets in AD and PD might serve as potential biomarkers, along with disease-specific gene sets. Besides, we also found the strong relationship between AD and immune infiltration. This research highlights the role of lncRNAs and their associated genes in PCD in neurodegenerative diseases, offering potential therapeutic targets and diagnostic markers for future study and clinical application.

Indexed as

Alzheimer DiseaseApoptosisParkinson DiseaseRNA, Long NoncodingAutophagyFerroptosisGene Expression RegulationGene Regulatory NetworksHumansProtein Interaction MapsRNA, MessengerRNA, Long NoncodingRNA, MessengerAlzheimer’s diseaselncRNAParkinson’s diseaseProgrammed cell death

Identifiers

PMID38853201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.