ArticleInsights into imaging2024
Non-Gaussian diffusion metrics with whole-tumor histogram analysis for bladder cancer diagnosis: muscle invasion and histological grade.
Article in Insights into imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Precise zonal diagnosis: multi-b-value DWI model reveals differential predictors of clinically significant prostate cancer in peripheral and transition zones.Insights into imaging · 2026Article
- Non-Gaussian diffusion MRI models for preoperative assessment of microvascular invasion in hepatocellular carcinoma.Abdominal radiology (New York) · 2026Article
- Non-Gaussian diffusion MRI using CTRW and FROC models for early treatment response assessment in nasopharyngeal carcinoma.BMC medical imaging · 2026Article
- Restricted spectrum imaging and diffusion kurtosis imaging for assessing lymph node metastasis in cervical cancer: a histogram analysis-based study.BMC cancer · 2025Article
- Parameter-driven habitat imaging based on intravoxel incoherent motion MRI for preoperative prediction of muscle invasion in bladder cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Imaging Features of Lung Ground-Glass Nodules and Their Correlation With Biological Behavior.Cureus · 2025Review
- Correlation between tumor stroma ratio, prognosis, and apparent diffusion coefficient in alveolar soft part sarcoma.European radiology · 2025Article
- Prediction of induction chemotherapy response in locoregionally advanced nasopharyngeal carcinoma based on three pretreatment non-Gaussian diffusion MRI models.BMC medical imaging · 2025Article
- Continuous-time random walk and fractional order calculus models histogram analysis of glioma biomarkers, includingQuantitative imaging in medicine and surgery · 2025Article
- Comparison of four MRI diffusion models to differentiate benign from metastatic retropharyngeal lymph nodes.European radiology experimental · 2025Article
- Histogram analysis of continuous-time random walk and restrictive spectrum imaging for identifying hepatocellular carcinoma and intrahepatic cholangiocarcinoma.Frontiers in oncology · 2025Article
- Using non-Gaussian diffusion models to distinguish benign from malignant head and neck lesions.Frontiers in oncology · 2025Article
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Authors and funding
10 authors.
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Abstract
purposeTo investigate the performance of histogram features of non-Gaussian diffusion metrics for diagnosing muscle invasion and histological grade in bladder cancer (BCa).
methodsPatients were prospectively allocated to MR scanner1 (training cohort) or MR2 (testing cohort) for conventional diffusion-weighted imaging (DWI
resultsMR1 included 267 pathologically-confirmed BCa patients (median age, 67 years [IQR, 46-82], 222 men) and MR2 included 83 (median age, 65 years [IQR, 31-82], 73 men). For discriminating muscle invasion, CTRW achieved the highest testing AUC of 0.915, higher than DWI
conclusionCTRW and IVIM are two potential non-Gaussian diffusion models to improve the MRI application in assessing muscle invasion and histological grade of BCa, respectively. CRITICAL RELEVANCE STATEMENT: Our study validates non-Gaussian diffusion imaging as a reliable, non-invasive technique for early assessment of muscle invasion and histological grade in BCa, enhancing accuracy in diagnosis and improving MRI application in BCa diagnostic procedures. KEY POINTS: Muscular invasion largely determines bladder salvageability in bladder cancer patients. Evaluated non-Gaussian diffusion metrics surpassed DWI
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