Evidence map›Paper›PMID 38853128›Full record

ArticleClinical and experimental reproductive medicine2024

The lncRNA Gm8097 is associated with hypospermatogenesis.

Bin Lei, Luwei Ye, Zhuolin Qiu, Shoubo Zhang

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Article in Clinical and experimental reproductive medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Bin LeiDepartment of Urology, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Luwei YeDepartment of Critical Care Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Zhuolin QiuDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Shoubo ZhangCenter for Reproductive Medicine, Guangdong Armed Police Hospital, Guangzhou Medical University, Guangzhou, China.

Funding

National Natural Science Foundation of China 81901464
6 · The paper itself

Abstract

objectiveTo investigate whether long non-coding RNA (lncRNA) Gm8097 (LncGm8097) is associated with male infertility.

methodsThe expression and bilogical role of LncGm8097 were investigated.

resultsLncGm8097 expression was down-regulated in the testis tissues with moderate and severe hypospermatogenesis compared with those with normal spermatogenesis and mild hypospermatogenesis (p<0.05). LncGm8097 down-regulation significantly promoted apoptosis and inhibited proliferation in GC1 and GC2 cells. In addition, LncGm8097 was significantly down-regulated in mouse model of hypospermatogenesis and correlated with cell apoptosis and proliferation. LncGm8097 was located immediately upstream of PRPS2, and correlated with Bcl-2/P53/caspase 6/caspase 9 signal pathway.

conclusionLncGm8097 down-regulation correlates with hypospermatogenesis, which may offer new insights into the pathogenesis of male infertility.

Indexed as

Infertility, maleOligospermiaPRPS2RNA, long noncodingSpermatogenesis

Identifiers

PMID38853128
PMCPMC11617910

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