Evidence map›Paper›PMID 38853120›Full record

ReviewTrends in genetics : TIG2024

Building the brain mosaic: an expanded view.

Sahibjot Sran, Amanda Ringland, Tracy A Bedrosian

Abstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Origins and timing of somatic variants in the brain.Current opinion in genetics & development · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sahibjot SranInstitute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Amanda RinglandInstitute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Tracy A BedrosianInstitute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA. Electronic address: Tracy.Bedrosian@NationwideChildrens.org.

Funding

Deciphering brain mosaicism in drug-resistant epilepsy at cellular resolutionR01NS129784 · NINDS · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Tracy Ann Bedrosian · 2023 to 2026
$2.2M
NINDS NIH HHS R01 NS129784
6 · The paper itself

Abstract

The complexity of the brain is closely tied to its nature as a genetic mosaic, wherein each cell is distinguished by a unique constellation of somatic variants that contribute to functional and phenotypic diversity. Postzygotic variation arising during neurogenesis is recognized as a key contributor to brain mosaicism; however, recent advances have broadened our understanding to include sources of neural genomic diversity that develop throughout the entire lifespan, from embryogenesis through aging. Moving beyond the traditional confines of neurodevelopment, in this review, we delve into the complex mechanisms that enable various origins of brain mosaicism.

Indexed as

BrainMosaicismAnimalsHumansNeurogenesisclonal lineagesdevelopmentembryogenesisneurogenesisselection, reversion

Identifiers

PMID38853120
PMCPMC11387136

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.