Evidence map›Paper›PMID 38852762›Full record

ArticleBrain, behavior, and immunity2024

Social fear extinction susceptibility is associated with Microbiota-Gut-Brain axis alterations.

Nathaniel L Ritz, Thomaz F S Bastiaanssen, Caitlin S M Cowan, Linda Smith, Nigel Theune, Marta Brocka, Eibhlís M Myers, Rachel D Moloney, Gerard M Moloney, Andrey N Shkoporov and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Microbiome: A Key Regulator of Body-Brain Interactions.Advances in experimental medicine and biology · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nathaniel L RitzAPC Microbiome Ireland, University College Cork, Cork T12YT20, Ireland; Dept. of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland.
Thomaz F S BastiaanssenAPC Microbiome Ireland, University College Cork, Cork T12YT20, Ireland; Dept. of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland.
Caitlin S M CowanAPC Microbiome Ireland, University College Cork, Cork T12YT20, Ireland; Dept. of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland.
Linda SmithAPC Microbiome Ireland, University College Cork, Cork T12YT20, Ireland; School of Microbiology, University College Cork, Cork, T12K8AF, Ireland.
Nigel TheuneAPC Microbiome Ireland, University College Cork, Cork T12YT20, Ireland; Dept. of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland.
Marta BrockaAPC Microbiome Ireland, University College Cork, Cork T12YT20, Ireland; Dept. of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland.
Eibhlís M MyersAPC Microbiome Ireland, University College Cork, Cork T12YT20, Ireland; Dept. of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland.
Rachel D MoloneyAPC Microbiome Ireland, University College Cork, Cork T12YT20, Ireland; Dept. of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland.
Gerard M MoloneyAPC Microbiome Ireland, University College Cork, Cork T12YT20, Ireland; Dept. of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland.
Andrey N ShkoporovAPC Microbiome Ireland, University College Cork, Cork T12YT20, Ireland; School of Microbiology, University College Cork, Cork, T12K8AF, Ireland.
Lorraine A DraperAPC Microbiome Ireland, University College Cork, Cork T12YT20, Ireland; School of Microbiology, University College Cork, Cork, T12K8AF, Ireland.
Colin HillAPC Microbiome Ireland, University College Cork, Cork T12YT20, Ireland; School of Microbiology, University College Cork, Cork, T12K8AF, Ireland.
Timothy G DinanAPC Microbiome Ireland, University College Cork, Cork T12YT20, Ireland; Dept. of Psychiatry and Neurobehavioural Science, University College Cork, Cork T12YT20, Ireland.
David A SlatteryDept. of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Frankfurt 60528, Germany.
John F CryanAPC Microbiome Ireland, University College Cork, Cork T12YT20, Ireland; Dept. of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland. Electronic address: J.Cryan@ucc.ie.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Social anxiety disorder is a common psychiatric condition that severely affects quality of life of individuals and is a significant societal burden. Although many risk factors for social anxiety exist, it is currently unknown how social fear sensitivity manifests biologically. Furthermore, since some individuals are resilient and others are susceptible to social fear, it is important to interrogate the mechanisms underpinning individual response to social fear situations. The microbiota-gut-brain axis has been associated with social behaviour, has recently been linked with social anxiety disorder, and may serve as a therapeutic target for modulation. Here, we assess the potential of this axis to be linked with social fear extinction processes in a murine model of social anxiety disorder. To this end, we correlated differential social fear responses with microbiota composition, central gene expression, and immune responses. Our data provide evidence that microbiota variability is strongly correlated with alterations in social fear behaviour. Moreover, we identified altered gene candidates by amygdalar transcriptomics that are linked with social fear sensitivity. These include genes associated with social behaviour (Armcx1, Fam69b, Kcnj9, Maoa, Serinc5, Slc6a17, Spata2, and Syngr1), inflammation and immunity (Cars, Ckmt1, Klf5, Maoa, Map3k12, Pex5, Serinc5, Sidt1, Spata2), and microbe-host interaction (Klf5, Map3k12, Serinc5, Sidt1). Together, these data provide further evidence for a role of the microbiota-gut-brain axis in social fear responses.

Indexed as

Brain-Gut AxisExtinction, PsychologicalFearGastrointestinal MicrobiomeMice, Inbred C57BLAmygdalaAnimalsAnxietyBrainDisease Models, AnimalMaleMicePhobia, SocialSocial BehaviorMicrobiomeSocial anxiety disorderSocial fear conditioningSocial phobia

Identifiers

PMID38852762
PMCPMC7619543

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.