Evidence map›Paper›PMID 38852580›Full record

ReviewHormone research in paediatrics2025

Sex Hormone Treatment for Female Children and Young Adults with Disorders Affecting Hypothalamic, Pituitary, and Ovarian Function.

Christoph Saner, Hannah Ochsner, Flurina Annacarina Maria Saner, Christa E Flück, Gabby Atlas, Anja Wueest, Margaret Zacharin, Christoph Saner

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Hormone research in paediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christoph Saner
Hannah OchsnerPediatric Endocrinology, Diabetology, and Metabolism, Department of Pediatrics, University Children's Hospital Bern, Inselspital Bern, Bern, Switzerland.
Flurina Annacarina Maria SanerDepartment of Obstetrics and Gynecology, University Hospital of Bern and University of Bern, Bern, Switzerland.
Christa E FlückPediatric Endocrinology, Diabetology, and Metabolism, Department of Pediatrics, University Children's Hospital Bern, Inselspital Bern, Bern, Switzerland.
Gabby AtlasDepartment of Endocrinology, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
Anja WueestDepartment of Obstetrics and Gynecology, University Hospital of Bern and University of Bern, Bern, Switzerland.
Margaret ZacharinDepartment of Endocrinology, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
Christoph SanerPediatric Endocrinology, Diabetology, and Metabolism, Department of Pediatrics, University Children's Hospital Bern, Inselspital Bern, Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNormal hypothalamic-pituitary-ovarian (HPO) endocrine function is essential for female pubertal and psychosocial development and for ongoing adult physical, sexual, and psychosocial health. Girls with hypogonadism, any endocrine disorder causing abnormal uterine bleeding (AUB) or with contraception needs may require sex hormone treatment. Challenges include evolving needs of a young girl through the course of sexual maturation, potential health risks related to the use of sex hormones for pubertal induction, hormone replacement therapy (HRT), menstrual management, and/or contraception. SUMMARY: To ensure optimal sex hormone treatment, both a comprehensive understanding of the underlying disorder affecting HPO endocrine function and a professional communication with the patient and physicians involved are warranted. In this narrative mini-review, we discuss pubertal induction and HRT for girls with hypogonadism and the management of AUB and contraception for young women up to age 30 years. Additionally, we provide advice on management of AUB and contraception in young women with common conditions including polycystic ovary syndrome, congenital adrenal hyperplasia and others. A PubMed-literature search including articles published over the last 20 years, together with clinical experience of the authors was integrated to provide treatment recommendations. KEY MESSAGE: Sex hormone treatment, where needed, requires comprehensive understanding of a range of available options. When tailored to individual needs, with flexibility to accommodate changing circumstance in young women it is safe, well tolerated and provides both physical and psychosocial health.

Indexed as

Adrenal Hyperplasia, CongenitalGonadal Steroid HormonesHormone Replacement TherapyHypogonadismHypothalamic DiseasesHypothalamo-Hypophyseal SystemOvaryPolycystic Ovary SyndromeAdolescentAdultChildFemaleHumansYoung AdultGonadal Steroid HormonesAdolescentsChildrenContraceptionHypothalamic-ovarian conditionsMenstrual managementSex hormone treatmentTransition

Identifiers

PMID38852580
PMCPMC12416880

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.