ArticlePediatric research2025
Dyspnea in young subjects with congenital central hypoventilation syndrome.
Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundIt has been stated that patients with congenital central hypoventilation syndrome (CCHS) do not perceive dyspnea, which could be related to defective CO
methodsWe retrospectively selected the data of six-minute walk tests (6-MWT, n = 30), cardiopulmonary exercise test (CPET, n = 5) of 30 subjects with CCHS (median age, 9.3 years, 17 females) who had both peripheral (controller loop gain, CG0) and central CO MAIN
resultsTen subjects had no symptom during the HHRT, as compared to the 20 subjects exhibiting symptoms, their median ages were 14.7 versus 8.8 years (p = 0.006), their maximal PETCO
conclusionAbout half of young subjects with CCHS do exhibit mild dyspnea at walk, which is not related to hypercapnia or residual CO IMPACT: Young subjects with CCHS exhibit some degree of dyspnea under CO
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