Evidence map›Paper›PMID 38851765›Full record

ArticleOrphanet journal of rare diseases2024

Plasma metabolomics signatures of developmental dysplasia of the hip in Tibet plateau.

Ye Guo, Xiaogang Li, De Yang, Nyima Yedron, Tao Chen, Jianchu Li, Yanming Lei, Ping Li, Jiamei Ji, Li Shi and 2 more

Abstract read
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In one paragraph

Article in Orphanet journal of rare diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ye Guo *Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Xiaogang Li *Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
De Yang *Department of Ultrasound, People's Hospital of Tibet Autonomous Region, No. 16, North Linkuo Road, Lhasa, Tibet, 850000, China.
Nyima YedronDepartment of Ultrasound, People's Hospital of Tibet Autonomous Region, No. 16, North Linkuo Road, Lhasa, Tibet, 850000, China.
Tao ChenDepartment of Ultrasound, Beijing Jishuitan Hospital, The 4th Clinical College, Peking University, Xinjiekou Dongjie, Xicheng District, Beijing, 100035, China.
Jianchu LiDepartment of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No. 1 Shuaifuyuan, Dong Cheng District, Beijing, 100730, China.
Yanming LeiDepartment of Radiology, People's Hospital of Tibet Autonomous Region, No. 16, North Linkuo Road, Lhasa, Tibet, 850000, China.
Ping LiDepartment of Infectious Diseases, People's Hospital of Tibet Autonomous Region, No.16, North Linkuo Road, Lhasa, Tibet, 850000, China.
Jiamei JiDepartment of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No. 1 Shuaifuyuan, Dong Cheng District, Beijing, 100730, China.
Li ShiDepartment of Laboratory Medicine, People's Hospital of Tibet Autonomous Region, No.16, North Linkuo Road, Lhasa, Tibet, 850000, China.
Xiao YangDepartment of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No. 1 Shuaifuyuan, Dong Cheng District, Beijing, 100730, China. yang_smile@163.com.ORCID 0000-0002-6454-5398
Ten ChoDepartment of Orthopedics, People's Hospital of Tibet Autonomous Region, No. 16, North Linkuo Road, Lhasa, Tibet, 850000, China. daneilwind@126.com.

Funding

High-level Hospital Construction Project of Guangdong Provincial People's Hospital 2022-PUMCH-A-057National High Level Hospital Clinical Research Funding 2022-PUMCH-A-263National High Level Hospital Clinical Research Funding 2022-PUMCH-C-053
6 · The paper itself

Abstract

backgroundDevelopmental dysplasia of the hip (DDH) is a common childhood health complaint, whose etiology is multifactorial. The incidence of DDH is variable and higher in Tibet plateau. Here, we collected plasma samples and studied the metabolomics signatures of DDH.

methodsFifty babies were enrolled: 25 with DDH and 25 age-matched non-DDH healthy controls (HC group). We collected plasma samples, laboratory parameters and conducted untargeted metabolomics profiling.

resultsThere are many differential metabolites among patients with DDH, including 4-β-hydroxymethyl-4-α-methyl-5-α-cholest-7-en-3-beta-ol, β-cryptoxanthin, α-tocopherol, taurocholic acid, glycocholic acid, 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate, arabinosylhypoxanthine, leucyl-hydroxyproline, hypoxanthine. The main differential metabolic pathways focused on primary bile acid biosynthesis, arginine and proline metabolism, phenylalanine metabolism, histidine metabolism, purine metabolism.

conclusionsTo our knowledge, this is the first report of metabolomics profile in babies with DHH. By combining the α-tocopherol and taurocholic acid, we could achieve the differential diagnosis of DDH.

Indexed as

Developmental Dysplasia of the HipMetabolomicsFemaleHumansInfantMaleTibetBiomarkerDevelopmental dysplasia of the hipMetabolomicsRare disease

Identifiers

PMID38851765
PMCPMC11161931

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.