Evidence map›Paper›PMID 38851737›Full record

ArticleBMC veterinary research2024

An insulin-like signalling pathway model for Fasciola gigantica.

Dongqi Wu, Yuqing Yang, Yankun Yang, Liang Li, Shishi Fu, Lei Wang, Li Tan, Xiuhong Lu, Weiyu Zhang, Wenda Di

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In one paragraph

Article in BMC veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Dongqi WuCollege of Animal Science and Technology, Guangxi University, Nanning, Guangxi, China.
Yuqing YangCollege of Animal Science and Technology, Guangxi University, Nanning, Guangxi, China.
Yankun YangCollege of Animal Science and Technology, Guangxi University, Nanning, Guangxi, China.
Liang LiCollege of Animal Science and Technology, Guangxi University, Nanning, Guangxi, China.
Shishi FuCollege of Animal Science and Technology, Guangxi University, Nanning, Guangxi, China.
Lei WangCollege of Animal Science and Technology, Guangxi University, Nanning, Guangxi, China.
Li TanWuhan Keqian Biology Limited Company, Wuhan, Hubei, China.
Xiuhong LuNanning Animal Disease Prevention and Control Center, Nanning, Guangxi, China.
Weiyu ZhangCollege of Animal Science and Technology, Guangxi University, Nanning, Guangxi, China.
Wenda DiCollege of Animal Science and Technology, Guangxi University, Nanning, Guangxi, China. diwenda@gxu.edu.cn.

Funding

Natural Science Foundation of Guangxi Zhuang Autonomous Region 2022GXNSFBA035583
6 · The paper itself

Abstract

backgroundThe insulin/insulin-like signalling (IIS) pathway is common in mammals and invertebrates, and the IIS pathway is unknown in Fasciola gigantica. In the present study, the IIS pathway was reconstructed in F. gigantica. We defined the components involved in the IIS pathway and investigated the transcription profiles of these genes for all developmental stages of F. gigantica. In addition, the presence of these components in excretory and secretory products (ESPs) was predicted via signal peptide annotation.

resultsThe core components of the IIS pathway were detected in F. gigantica. Among these proteins, one ligand (FgILP) and one insulin-like molecule binding protein (FgIGFBP) were analysed. Interestingly, three receptors (FgIR-1/FgIR-2/FgIR-3) were detected, and a novel receptor, FgIR-3, was screened, suggesting novel functions. Fg14-3-3ζ, Fgirs, and Fgpp2a exhibited increased transcription in 42-day-old juveniles and 70-day-old juveniles, while Fgilp, Fgigfb, Fgsgk-1, Fgakt-1, Fgir-3, Fgpten, and Fgaap-1 exhibited increased transcription in metacercariae. FgILP, FgIGFBP, FgIR-2, FgIR-3, and two transcription factors (FgHSF-1 and FgSKN-1) were predicted to be present in FgESPs, indicating their exogenous roles.

conclusionsThis study helps to elucidate the signal transduction pathway of IIS in F. gigantica, which will aid in understanding the interaction between flukes and hosts, as well as in understanding fluke developmental regulation, and will also lay a foundation for further characterisation of the IIS pathways of trematodes.

Indexed as

FasciolaHelminth ProteinsInsulinSignal TransductionAnimalsHelminth ProteinsInsulinESPFasciola giganticaInsulin signalling pathwayTranscriptionTrematode

Identifiers

PMID38851737
PMCPMC11162077

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