Evidence map›Paper›PMID 38851644›Full record

ArticleEndocrine2024

The impact of bone mineral density on the risk of falling: evidence from genetic correlation and Mendelian randomization analysis.

Rumeng Mao, Luyao Peng, Youqian Zhang, Lin Li, Yanrui Ren

Abstract read
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In one paragraph

Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rumeng Mao *Department of Endocrinology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei Province, China.
Luyao Peng *Department of Endocrinology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei Province, China.
Youqian ZhangHealth Science Center, Yangtze University, Jingzhou, Hubei Province, China.
Lin LiDepartment of Endocrinology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei Province, China. 2022721046@yangtzeu.edu.cn.
Yanrui RenDepartment of Endocrinology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei Province, China. 709064048@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFalls are the most common consequence of low bone mineral density (BMD). However, due to limitations inherent in observational studies, the causal relationship between the two remains unestablished.

methodsThis study utilized Mendelian Randomization (MR) analysis to explore the causal relationship between BMD and the risk of falling, incorporating linkage disequilibrium score (LDSC) regression for genetic correlation assessment. The primary method was inverse-variance weighted (IVW), supplemented with sensitivity analyses and the causal analysis using summary effect estimates (CAUSE) to address heterogeneity and pleiotropy biases.

resultsLDSC analysis indicated significant genetic correlations between BMD at various sites and falling risk (r

conclusionThe study established a causal relationship between BMD at four different sites and the risk of falling, highlighting potential areas for targeted prevention strategies.

Indexed as

Accidental FallsBone DensityMendelian Randomization AnalysisFemaleFemur NeckHumansLinkage DisequilibriumMaleOsteoporosisPolymorphism, Single NucleotideRisk FactorsBone mineral densityFallLinkage disequilibrium scoreMendelian randomization

Identifiers

PMID38851644

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.