Evidence map›Paper›PMID 38851562›Full record

ArticleEuropean journal of pharmacology2024

Inhibition of TRPC3 channels suppresses seizure susceptibility in the genetically-epilepsy prone rats.

Gleice K Silva-Cardoso, Vijay K Boda, Wei Li, Prosper N'Gouemo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gleice K Silva-CardosoDepartment of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, 20059, USA.
Vijay K BodaDepartment of Pharmaceutical Sciences and Drug Discovery Center, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA.
Wei LiDepartment of Pharmaceutical Sciences and Drug Discovery Center, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA.
Prosper N'GouemoDepartment of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, 20059, USA. Electronic address: prosper.ngouemo@howard.edu.

Funding

Na+/Ca2+ exchanger remodeling in alcohol withdrawal seizuresR01AA027660 · NIAAA · HOWARD UNIVERSITY · PI N'GOUEMO, PROSPER · 2019 to 2023
$1.7M
Targeting TRPC3 Channels for Epileptic SeizuresR61NS124923 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JIANG, JIANXIONG, LI, WEI · 2022 to 2023
$765k
Developing a selective TRPC3 ion channel inhibitor for epilepsy treatmentR41NS135658 · NINDS · SEAK THERAPEUTICS, LLC · PI LI, WEI · 2023 to 2023
$430k
NIAAA NIH HHS R01 AA027660NINDS NIH HHS R41 NS135658NINDS NIH HHS R61 NS124923
6 · The paper itself

Abstract

Transient receptor potential canonical 3 (TRPC3) channels are important in regulating Ca

Indexed as

SeizuresTRPC Cation ChannelsAnimalsAnticonvulsantsEpilepsyFemaleGenetic Predisposition to DiseaseMaleRatsAnticonvulsantsTRPC3 cation channelTRPC Cation ChannelsBrainstem seizuresCalcium signalingGeneralized tonic-clonic seizuresInherited epilepsyTRPC3 channels

Identifiers

PMID38851562
PMCPMC11295865

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.