Evidence map›Paper›PMID 38851531›Full record

ArticleNeuropharmacology2024

Decoupling of cortical activity from behavioral state following administration of the classic psychedelic DOI.

Randall J Olson, Lowell Bartlett, Alex Sonneborn, Russell Milton, Zachary Bretton-Granatoor, Ayesha Firdous, Alexander Z Harris, Atheir I Abbas

Abstract read
In one paragraph

Article in Neuropharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Randall J OlsonDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland OR 97239, USA.
Lowell BartlettDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland OR 97239, USA.
Alex SonnebornDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland OR 97239, USA.
Russell MiltonDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland OR 97239, USA.
Zachary Bretton-GranatoorDivision of Integrative Neuroscience, New York State Psychiatric Institute, New York, NY 10034, USA.
Ayesha FirdousDivision of Integrative Neuroscience, New York State Psychiatric Institute, New York, NY 10034, USA.
Alexander Z HarrisDivision of Integrative Neuroscience, New York State Psychiatric Institute, New York, NY 10034, USA; Department of Psychiatry, Columbia University, New York, NY, 10034, USA.
Atheir I AbbasDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland OR 97239, USA; Department of Psychiatry, Oregon Health and Science University, Portland OR 97239, USA; VA Portland Health Care System, Portland OR, 97239, USA. Electronic address: abbasat@ohsu.edu.

Funding

BIOLOGICAL BASES OF ALCOHOLISMT32AA007468 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Andrey E Ryabinin · 1987 to 2026
$11.3M
Training in Schizophrenia and Psychotic Disorders: From Animal Models to PatientsT32MH018870 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Guillermo Horga, Christoph Kellendonk · 1988 to 2026
$9.8M
BIOLOGICAL BASES OF DRUG-SEEKING BEHAVIORT32DA007262 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 1991 to 2022
$9.4M
VTA-NAc GABAergic communication underlying stress-induced reward deficitsR01MH124998 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI HARRIS, ALEXANDER · 2021 to 2025
$2.9M
NIAAA NIH HHS T32 AA007468NIDA NIH HHS T32 DA007262NIMH NIH HHS R01 MH124998NIMH NIH HHS T32 MH018870
6 · The paper itself

Abstract

Administration or consumption of classic psychedelics (CPs) leads to profound changes in experience which are often described as highly novel and meaningful. They have shown substantial promise in treating depressive symptoms and may be therapeutic in other situations. Although research suggests that the therapeutic response is correlated with the intensity of the experience, the neural circuit basis for the alterations in experience caused by CPs requires further study. The medial prefrontal cortex (mPFC), where CPs have been shown to induce rapid, 5-HT

Indexed as

AmphetaminesHallucinogensPrefrontal CortexAction PotentialsAnimalsBehavior, AnimalMaleMiceMice, Inbred C57BLNeurons4-iodo-2,5-dimethoxyphenylisopropylamineAmphetaminesHallucinogensBehavioral stateCortexDeltaDesynchronizationDOIGammaHallucinogenPrefrontal cortexPsychedelicSerotonin

Identifiers

PMID38851531
PMCPMC11260522

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.