Evidence map›Paper›PMID 38850531›Full record

ArticleCell reports2024

The interaction between RIPK1 and FADD controls perinatal lethality and inflammation.

Diego A Rodriguez, Bart Tummers, Jeremy J P Shaw, Giovanni Quarato, Ricardo Weinlich, James Cripps, Patrick Fitzgerald, Laura J Janke, Stephane Pelletier, Jeremy Chase Crawford and 1 more

Abstract read
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Mechanisms, regulation and clinical relevance of necroptosis.Nature reviews. Molecular cell biology · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Review
  9. Review
  10. For Better or Worse: The Impact of Necrotic Cell Death Modalities.Advances in experimental medicine and biology · 2025
    Review
  11. Review
  12. PANoptosis: a new insight for oral diseases.Molecular biology reports · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Diego A RodriguezDepartment of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Bart TummersCentre for Inflammation Biology & Cancer Immunology (CIBCI), Department of Inflammation Biology, School of Immunology & Microbial Sciences, King's College London, London SE1 1UL, UK. Electronic address: bart.tummers@kcl.ac.uk.
Jeremy J P ShawDepartment of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Giovanni QuaratoDepartment of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA; Treeline Biosciences, San Diego, CA 92121, USA.
Ricardo WeinlichHospital Israelita Albert Einstein, São Paulo, Brazil.
James CrippsCenter for Cancer Immunology and Immunotherapy, Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA.
Patrick FitzgeraldDepartment of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Laura J JankeDepartment of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Stephane PelletierDepartment of Medical and Molecular Genetics, Indiana University Genome Editing Center, Indiana University School of Medicine, Indiana University, Indianapolis, IA 46902, USA.
Jeremy Chase CrawfordDepartment of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Douglas R GreenDepartment of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address: douglas.green@stjude.org.

Funding

MECHANISMS OF REGULATED CELL DEATHR35CA231620 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Douglas R. Green · 2018 to 2026
$9.2M
Survival Function of the Fadd-Caspase-8-Flip ComplexR01AI044828 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GREEN, DOUGLAS R. · 1999 to 2016
$6.3M
Survival Function of the Fadd-Caspase-8-Flip Complex - MERIT ExtensionR37AI044828 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Douglas R. Green · 2017 to 2026
$4.5M
T32 Training Program in Pediatric Immuno-Oncology and ImmunotherapyT32CA272387 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Stephen Gottschalk · 2022 to 2026
$994k
NCI NIH HHS R35 CA231620NIAID NIH HHS R01 AI044828NIAID NIH HHS R37 AI044828
6 · The paper itself

Abstract

Perturbation of the apoptosis and necroptosis pathways critically influences embryogenesis. Receptor-associated protein kinase-1 (RIPK1) interacts with Fas-associated via death domain (FADD)-caspase-8-cellular Flice-like inhibitory protein long (cFLIP

Indexed as

Caspase 8Fas-Associated Death Domain ProteinInflammationReceptor-Interacting Protein Serine-Threonine KinasesAnimalsApoptosisMiceMice, Inbred C57BLNecroptosisProtein BindingProtein KinasesRNA-Binding ProteinsCaspase 8Fadd protein, mouseFas-Associated Death Domain ProteinMLKL protein, mouseProtein KinasesReceptor-Interacting Protein Serine-Threonine KinasesRipk1 protein, mouseRipk3 protein, mouseRNA-Binding ProteinsZbp1 protein, mouseapoptosisCaspase-8CP: ImmunologyMLKLnecroptosisRIPK1RIPK3ZBP1

Identifiers

PMID38850531
PMCPMC11256114

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.