Evidence map›Paper›PMID 38850470›Full record

ArticleCardiovascular toxicology2024

Inhibition of Extracellular Signal-Regulated Kinase Activity Improves Cognitive Function in Mice Subjected to Myocardial Infarction.

Yibo Yin, Xin Li, Xiaoxua Zhang, Xinru Yuan, Xingji You, Jingxiang Wu

Abstract read
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In one paragraph

Article in Cardiovascular toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yibo Yin *Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, School of Medicine, No. 241 West Huaihai Rd., Shanghai, China.
Xin Li *School of Medical Instrument and Food Engineering USST, University of Shanghai for Science and Technology, Shanghai, China.
Xiaoxua ZhangSchool of Medicine, Shanghai University, No. 99 Shangda Road, Baoshan District, Shanghai, 200444, China.
Xinru YuanSchool of Medicine, Shanghai University, No. 99 Shangda Road, Baoshan District, Shanghai, 200444, China.
Xingji YouSchool of Medicine, Shanghai University, No. 99 Shangda Road, Baoshan District, Shanghai, 200444, China. yoyo1976@shu.edu.cn.
Jingxiang WuDepartment of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, School of Medicine, No. 241 West Huaihai Rd., Shanghai, China. wu_jingxiang@sjtu.edu.cn.

Funding

National Natural Science Foundation of China 82071233Shanghai Shen Kang Hospital Development Center Project SHDC2020CR4063
6 · The paper itself

Abstract

Cognitive impairment is a commonly observed complication following myocardial infarction; however, the underlying mechanisms are still not well understood. The most recent research suggests that extracellular signal-regulated kinase (ERK) plays a critical role in the development and occurrence of cognitive dysfunction-related diseases. This study aims to explore whether the ERK inhibitor U0126 targets the ERK/Signal Transducer and Activator of Transcription 1 (STAT1) pathway to ameliorate cognitive impairment after myocardial infarction. To establish a mouse model of myocardial infarction, we utilized various techniques including Echocardiography, Hematoxylin-eosin (HE) staining, Elisa, Open field test, Elevated plus maze test, and Western blot analysis to assess mouse cardiac function, cognitive function, and signal transduction pathways. For further investigation into the mechanisms of cognitive function and signal transduction, we administered the ERK inhibitor U0126 via intraperitoneal injection. Reduced total distance and activity range were observed in mice subjected to myocardial infarction during the open field test, along with decreased exploration of the open arms in the elevated plus maze test. However, U0126 treatment exhibited a significant improvement in cognitive decline, indicating a protective effect through the inhibition of the ERK/STAT1 signaling pathway. Hence, this study highlights the involvement of the ERK/STAT1 pathway in regulating cognitive dysfunction following myocardial infarction and establishes U0126 as a promising therapeutic target.

Indexed as

Behavior, AnimalButadienesCognitionDisease Models, AnimalExtracellular Signal-Regulated MAP KinasesMice, Inbred C57BLMyocardial InfarctionNitrilesSTAT1 Transcription FactorAnimalsCognitive DysfunctionElevated Plus Maze TestMaleMiceOpen Field TestProtein Kinase InhibitorsButadienesExtracellular Signal-Regulated MAP KinasesNitrilesProtein Kinase InhibitorsStat1 protein, mouseSTAT1 Transcription FactorU 0126Animal modelBehavioral experimentCardiovascular diseaseExtracesllular signal-regulated kinaseU0126

Identifiers

PMID38850470

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.