Evidence map›Paper›PMID 38850388›Full record

ArticleBrain imaging and behavior2024

Age exacerbates the negative effect of depression on executive functioning in racial and ethnic minorities.

Zhimei Niu, Andreana P Haley, Alexandra L Clark, Audrey Duarte

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In one paragraph

Article in Brain imaging and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Zhimei NiuDepartment of Psychology, University of Texas at Austin, 108 Dean Keeton Street, Austin, TX, 78712, USA. zhimei.niu@austin.utexas.edu.
Andreana P HaleyDepartment of Psychology, University of Texas at Austin, 108 Dean Keeton Street, Austin, TX, 78712, USA.
Alexandra L ClarkDepartment of Psychology, University of Texas at Austin, 108 Dean Keeton Street, Austin, TX, 78712, USA.
Audrey DuarteDepartment of Psychology, University of Texas at Austin, 108 Dean Keeton Street, Austin, TX, 78712, USA.

Funding

Neuroimaging Cognitive Vulnerability in HypertensionR01NS075565 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI HALEY, ANDREANA PETROVA · 2011 to 2013
$986k
National Institute of Health R01NS75565NINDS NIH HHS R01 NS075565
6 · The paper itself

Abstract

Age and depression may interact to produce a "double jeopardy" for cognitive impairment, and executive functioning, in cognitively unimpaired aging. Few studies have considered middle age or the ethnoracial diversity of subjects, despite evidence of more severe cognitive outcomes in historically minoritized people. In this pilot study, we investigated the impact of age on depression-related cognitive impairment and the underlying brain volumes in middle-aged non-Hispanic White adults (116), and Hispanic and Black adults (60), with a total number of 176 adults. The result shows a significant interaction between age and depression for executive functioning, specifically for middle-aged Hispanic and Black adults, but not non-Hispanic White adults. Prefrontal cortex volumes, which were reduced in the Black and Hispanic compared to the non-Hispanic White adults, partially mediated the relationship between depression level and executive functioning, across age and ethnoracial group. Collectively, these results suggest that the negative impact of depression on executive functioning and Prefrontal cortex volumes integrity may be exacerbated by age and that historically minoritized people may be particularly sensitive to this double jeopardy.

Indexed as

AgingDepressionExecutive FunctionAdultAgedBlack or African AmericanBrainCognitive DysfunctionEthnic and Racial MinoritiesFemaleHispanic or LatinoHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsAgingCognitive impairmentDepressionEthnoracial diversityPrefrontal cortex volumes

Identifiers

PMID38850388
PMCPMC11582303

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.