Evidence map›Paper›PMID 38850386›Full record

ArticleNeuroscience bulletin2024

Modulation of Nicotine-Associated Behaviour in Rats By μ-Opioid Signals from the Medial Prefrontal Cortex to the Nucleus Accumbens Shell.

Feng Zhu, Hirosato Kanda, Hiroyuki Neyama, Yuping Wu, Shigeki Kato, Di Hu, Shaoqi Duan, Koichi Noguchi, Yasuyoshi Watanabe, Kazuto Kobayashi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Progress in pain mechanisms and management.Signal transduction and targeted therapy · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Feng ZhuDepartment of Anatomy and Neuroscience, Hyogo Medical University, Nishinomiya, Hyogo, 663-8501, Japan.ORCID http://orcid.org/0009-0001-7649-8525
Hirosato KandaSchool of Pharmacy, Hyogo Medical University, Kobe, Hyogo, 650-8530, Japan.
Hiroyuki NeyamaRIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo, 650-0047, Japan.ORCID http://orcid.org/0000-0003-3351-9813
Yuping WuRIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo, 650-0047, Japan.
Shigeki KatoDepartment of Molecular Genetics, Fukushima Medical University Institute of Biomedical Sciences, Fukushima, 960-1295, Japan.
Di HuRIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo, 650-0047, Japan.
Shaoqi DuanDepartment of Anatomy and Neuroscience, Hyogo Medical University, Nishinomiya, Hyogo, 663-8501, Japan.
Koichi NoguchiDepartment of Anatomy and Neuroscience, Hyogo Medical University, Nishinomiya, Hyogo, 663-8501, Japan.
Yasuyoshi WatanabeRIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo, 650-0047, Japan.
Kazuto KobayashiDepartment of Molecular Genetics, Fukushima Medical University Institute of Biomedical Sciences, Fukushima, 960-1295, Japan.
Yi DaiDepartment of Anatomy and Neuroscience, Hyogo Medical University, Nishinomiya, Hyogo, 663-8501, Japan. ydai@hyo-med.ac.jp.
Yilong CuiDepartment of Anatomy and Neuroscience, Hyogo Medical University, Nishinomiya, Hyogo, 663-8501, Japan. cuiyl@riken.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nicotine addiction is a concern worldwide. Most mechanistic investigations are on nicotine substance dependence properties based on its pharmacological effects. However, no effective therapeutic treatment has been established. Nicotine addiction is reinforced by environments or habits. We demonstrate the neurobiological basis of the behavioural aspect of nicotine addiction. We utilized the conditioned place preference to establish nicotine-associated behavioural preferences (NABP) in rats. Brain-wide neuroimaging analysis revealed that the medial prefrontal cortex (mPFC) was activated and contributed to NABP. Chemogenetic manipulation of µ-opioid receptor positive (MOR

Indexed as

NicotineNucleus AccumbensPrefrontal CortexReceptors, Opioid, muAnimalsMaleNeural PathwaysNeuronsRatsRats, Sprague-DawleyTobacco Use DisorderNicotineReceptors, Opioid, muMedial prefrontal cortexNicotine-associated behaviourNucleus accumbens shellSmall-animal neuroimagingμ-Opioid receptor

Identifiers

PMID38850386
PMCPMC11625037

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.