Evidence map›Paper›PMID 38850336›Full record

Trial reportArchives of dermatological research2024

Long-pulsed nd: YAG laser treatment of nail psoriasis: clinical and ultrasonographic assessment.

Mohamed Ahmed Salem El-Basiony, Mohamed Hussein Medhat El-Komy, Nevien Ahmed Samy, Dalia Gamal Aly, Hala El-Gendy, Mohamed Fouad Abdel Salam Hassan, Hagar El Sayed, Mohamed Mohsen Soliman

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of dermatological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohamed Ahmed Salem El-BasionyDepartment of Dermatology and Venereology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt.
Mohamed Hussein Medhat El-KomyDepartment of Dermatology, Kasr Al-Ainy Psoriasis Unit, Faculty of Medicine, Cairo University, Giza, Egypt.
Nevien Ahmed SamyDermatology Unit, Department of Medical Applications of Lasers, National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt.
Dalia Gamal AlyDepartment of Dermatology and Venereology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt.
Hala El-GendyDepartment of Internal Medicine and Rheumatology, Faculty of Medicine, Cairo University, Giza, Egypt.
Mohamed Fouad Abdel Salam HassanDepartment of Dermatology and Venereology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt.
Hagar El SayedDepartment of Dermatology, Kasr Al-Ainy Psoriasis Unit, Faculty of Medicine, Cairo University, Giza, Egypt. hagar.elsayed@kasralainy.edu.eg.ORCID http://orcid.org/0000-0002-6641-8456
Mohamed Mohsen SolimanDermatology Unit, Department of Medical Applications of Lasers, National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nail psoriasis is a chronic, inflammatory condition which is difficult to treat, linked with greater psoriasis severity, and may be associated with anxiety and significant functional impairment of the quality of life. The 1064 nm Nd: YAG laser was reported to yield satisfactory results in the treatment of nail psoriasis.The aim of the study was to assess the clinical and ultrasonographic efficacy of long-pulsed 1064 nm Nd: YAG laser in the treatment of fingernail psoriasis and compare its effect to control fingernails.This intra-patient randomized controlled trial analyzed 86 fingernails collected from 13 patients suffering from cutaneous and nail psoriasis. The nails were randomized into two groups. Group A was treated with Nd: YAG laser once monthly for three sessions while group B served as control. Assessment took place at baseline, 1 and 3 months after the last treatment session. For scoring, the 32-points target NAPSI scoring systems was used. Additionally, two blinded dermatologists' score of improvement, patients' pain assessment by visual analogue score and ultrasonographic assessment were all performed.At the end of follow up, the medians of tNAPSI score, plate definition, matrix thickness, bed thickness and bed vascularity decreased significantly in the Nd: YAG laser treated group in comparison to baseline (p = 0.001, 0.006, 0.039, < 0.001 and 0.010, respectively). While, there was a non-significant reduction in median tNAPSI score in the control group at last follow up, however, ultrasonography recorded a significant reduction in the medians of plate definition, bed thickness and vascularity (p = 0.002, 0.011 and 0.033, respectively) from the baseline. Comparison of the Nd: YAG laser and the control groups showed no significant difference from baseline regarding the medians of tNAPSI, tNAPSI percentile improvement, pits count, blinded evaluation of photographs and ultrasonographic assessments.In conclusion, Nd: YAG laser showed clinical and ultrasonographic improvement in fingernail psoriasis. Ultrasonography is a useful noninvasive tool in diagnosing and monitoring the clinical and even the subclinical changes in nail psoriasis. Nail psoriasis although difficult to treat, may show spontaneous improvement.

Indexed as

Lasers, Solid-StateNail DiseasesPsoriasisUltrasonographyAdultFemaleHumansLow-Level Light TherapyMaleMiddle AgedNailsPain MeasurementQuality of LifeSeverity of Illness IndexTreatment OutcomeYoung AdultNail psoriasisNd:YAG laserTarget NAPSIUltrasonography

Identifiers

PMID38850336
PMCPMC11162362

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.