Evidence map›Paper›PMID 38850312›Full record

ArticleArchives of dermatological research2024

Aberrant expression of B7-H4 and B7-H5 contributes to the development of cutaneous squamous cell carcinoma.

Lu Chen, Bin Zhou, Minhui Tang, Yuxu Yao, Yue Zhao, Ying Hu, Yuxin Lin, Jiang Ji, Qingqing Jiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of dermatological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lu Chen *Department of Dermatology, The First Affiliated Hospital of Soochow University, Shizi Road 188, Suzhou, 215006, China.
Bin Zhou *Jiangsu Institute of Clinical Immunology and Jiangsu Key Laboratory of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Minhui Tang *Department of Dermatology, The First Affiliated Hospital of Soochow University, Shizi Road 188, Suzhou, 215006, China.
Yuxu YaoDepartment of Dermatology, The Second Affiliated Hospital of Soochow University, Sangxiang Road 1055, Suzhou, 215004, China.
Yue ZhaoDepartment of Dermatology, The First Affiliated Hospital of Soochow University, Shizi Road 188, Suzhou, 215006, China.
Ying HuDepartment of Dermatology, The First Affiliated Hospital of Soochow University, Shizi Road 188, Suzhou, 215006, China.
Yuxin LinDepartment of Dermatology, The First Affiliated Hospital of Soochow University, Shizi Road 188, Suzhou, 215006, China.
Jiang JiDepartment of Dermatology, The Second Affiliated Hospital of Soochow University, Sangxiang Road 1055, Suzhou, 215004, China. jijiang@suda.edu.cn.
Qingqing JiaoDepartment of Dermatology, The First Affiliated Hospital of Soochow University, Shizi Road 188, Suzhou, 215006, China. qingqingjiao@suda.edu.cn.

Funding

National Natural Science Foundation of China 82073434
6 · The paper itself

Abstract

Cutaneous squamous cell carcinoma (CSCC) is the second most common malignant tumor of the skin. B7 homolog 4 (B7-H4) and B7-H5 (B7 homolog 5) are associated with a variety of tumors. Investigate the potential role of B7-H4 and B7-H5 in regulating the tumorigenesis and progression of CSCC. B7-H4 and B7-H5 transcriptome data were collected from GEO and TCGA databases and subjected to bioinformatical analysis by protein-protein interaction (PPI) network, functional enrichment analysis, immune analysis, and drug-gene interaction prediction analysis. We characterized the expression of B7-H4 and B7-H5 in carcinoma tissues of CSCC patients by immunohistochemistry. Meanwhile, the clinical correlation of B7-H4 and B7-H5 in CSCC was explored by statistical analysis. B7-H4 and B7-H5 genes were under-expressed in CSCC and correlated with tumor staging. According to GO and KEGG Pathway enrichment analysis, B7-H4, and B7-H5 can regulate the proliferation and activation of T cells, lymphocytes, and monocytes, and the expression of cytokines, such as IL-6 and IL-10, in CSCC. B7-H4 and B7-H5 are also jointly involved in the occurrence and development of CSCC via the JAK-STAT and Notch signaling pathways. We found that B7-H4 and B7-H5 proteins were abnormally highly expressed in CSCC tissue and correlated with tumor size and stage. Our findings offer new insights into the pathogenesis of CSCC and suggest that B7-H4 and B7-H5 are novel tissue biomarkers and promising therapeutic targets for CSCC.

Indexed as

Carcinoma, Squamous CellGene Expression Regulation, NeoplasticSkin NeoplasmsV-Set Domain-Containing T-Cell Activation Inhibitor 1AgedB7 AntigensBiomarkers, TumorFemaleHumansImmunoglobulinsMaleMiddle AgedNeoplasm StagingProtein Interaction MapsSignal TransductionB7 AntigensBiomarkers, TumorHHLA2 protein, humanImmunoglobulinsV-Set Domain-Containing T-Cell Activation Inhibitor 1VSIR protein, humanVTCN1 protein, humanB7-H4B7-H5Bioinformatical analysisCutaneous squamous cell carcinomaSquamous cell carcinomaTumor microenvironment

Identifiers

PMID38850312
PMCPMC11162363

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.