Evidence map›Paper›PMID 38850311›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

Non-invasive visualization of liver fibrosis with [

Yangmeihui Song, Chunxia Qin, Yixiong Chen, Weiwei Ruan, Yongkang Gai, Wenyu Song, Yu Gao, Wenzhu Hu, Pengxin Qiao, Xiangming Song and 6 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04605939 (Clinical Application of Fibroblast Activation Protein PET/MRI for Diagnosis and Staging in Liver Fibrosis), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04605939 naunknown statusnot on this map

Clinical Application of Fibroblast Activation Protein PET/MRI for Diagnosis and Staging in Liver Fibrosis

TypeinterventionalSponsorUnion Hospital, Tongji Medical College, Huazhong University of Science and TechnologyRan2020 to 2023Enrolled100ConditionsLiver Fibrosis, Positron Emission Tomography, Magnetic Resonance ImagingArmsPET/MR, PET/CT
3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Assessment of liver fibrosis and tumor burden in hepatocellular carcinoma using [European journal of nuclear medicine and molecular imaging · 2026
    Trial
  2. Article
  3. FAP-targeted [European journal of nuclear medicine and molecular imaging · 2026
    Article
  4. [Scientific reports · 2026
    Article
  5. Article
  6. Article
  7. A pilot human-based study ofScientific reports · 2026
    Article
  8. Performance of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  9. FAPI TracerPharmaceuticals (Basel, Switzerland) · 2025
    Article
  10. Review
  11. Article
  12. Efficacy of [Annals of nuclear medicine · 2025
    Article
  13. Review
  14. CombinedFrontiers in medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yangmeihui Song *Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.
Chunxia Qin *Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.
Yixiong ChenDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.
Weiwei RuanDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.
Yongkang GaiDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.
Wenyu SongDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.
Yu GaoDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.
Wenzhu HuDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.
Pengxin QiaoDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.
Xiangming SongDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.
Xiaoying LvDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.
Danzha ZhengDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.
Huikuan ChuDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.
Dawei JiangDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.
Ling YangDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China. hepayang@163.com.
Xiaoli LanDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China. xiaoli_lan@hust.edu.cn.ORCID 0000-0002-7263-7399

Funding

Key Project of Hubei Natural Science Foundation 2021CFA008National Natural Science Foundation of China 82030052National Natural Science Foundation of China 82171985Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 2021xh1cyj12
6 · The paper itself

Abstract

purposeThe reversibility of early liver fibrosis highlights the need for improved early detection and monitoring techniques. Fibroblast activation protein (FAP) is a promising theranostics target significantly upregulated during fibrosis. This preclinical and preliminary clinical study investigated a FAP-targeted probe, gallium-68-labeled FAP inhibitor 04 ([

methodsThe preclinical study employed [

results[

conclusion[

trial registrationNCT04605939. Registered October 25, 2020, https://clinicaltrials.gov/study/NCT04605939.

Indexed as

Liver CirrhosisPositron Emission Tomography Computed TomographyAdultAgedAnimalsEndopeptidasesFemaleFibroblast Activation Protein AlphaGallium RadioisotopesHeterocyclic Compounds, 1-RingHumansLiverMaleMembrane ProteinsMiceMiddle Aged1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidEndopeptidasesFibroblast Activation Protein AlphaGallium-68Gallium RadioisotopesHeterocyclic Compounds, 1-RingMembrane ProteinsRadiopharmaceuticalsFibroblast activation proteinFibroblast activation protein inhibitorLiver fibrosisNon-alcoholic steatohepatitisPositron emission tomography

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.