ArticleJournal of analytical toxicology2024
Difficulties associated with the interpretation of postmortem toxicology.
Article in Journal of analytical toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Postmortem Oxycodone Toxicology: A Systematic Review and Meta-Analysis of Concentrations and Interpretative Markers.Molecules (Basel, Switzerland) · 2026Pooled it
- Quality assessment of the forensic surveillance system: A data-quality monitoring system for substance-abuse detection in unnatural deaths in Thailand.Forensic science international. Synergy · 2026Article
- Interpol review of forensic toxicology, 2023-2025.Forensic science international. Synergy · 2026Review
- Development and validation of a multi-matrix LC-MS/MS method for quantification of 20 drugs in human postmortem and porcine surrogate matrices.Analytical and bioanalytical chemistry · 2026Article
- Thinking beyond blood: brain concentrations and brain-blood ratios in postmortem toxicology.Journal of analytical toxicology · 2026Article
- A Forensic Approach to Perioperative Deaths After Non-Cardiac Surgery: A Narrative Review.Diagnostics (Basel, Switzerland) · 2026Review
- Benefits and Limitations Associated with the Use of Alternative Biological Matrices in Forensic Toxicology, as Well as Genetic Markers of Poisoning and Psychoactive Substance Abuse.International journal of molecular sciences · 2026Review
- From blood to brain: postmortem brain concentrations and brain-blood ratios of chlorprothixene, clozapine, olanzapine, and quetiapine.Journal of analytical toxicology · 2026Article
- Antidepressant metabolite concentrations and metabolite-to-parent drug ratios in postmortem femoral blood.Journal of analytical toxicology · 2026Article
- Postmortem Aqueous Humor Analysis in Pigs as an Index of Antemortem Serum Biochemistry Profile and Diagnostic Aid in Animal Welfare.Animals : an open access journal from MDPI · 2026Article
- Deep learning and object detection methods for scoring cell types within the human buccal cell micronucleus and cytome assays for human biomonitoring.Mutagenesis · 2026Review
- Postmortem Redistribution of Drugs Commonly Used in Rapid Sequence Induction for Anesthesia: A Review.Journal of clinical medicine · 2026Review
- Decomposition and medicolegal autopsy in geriatric in‑home non‑traumatic deaths: histopathological findings and a public health perspective.BMC geriatrics · 2026Article
- Synthetic cannabinoids in human post-mortem samples - ADB-BUTINACA and metabolites in three fatalities.Frontiers in toxicology · 2026Article
- Review
- Evaluating the value of entomotoxicology in forensic toxicology casework using the first minipig model.Forensic toxicology · 2025Article
- Influence of a Zombie-like State of the Liver on Drugs and Its Medico-Legal Implications: A Scoping Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Ancillary and Advanced Techniques for the Postmortem Examination.Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology SocietyReview
- Toxicology Testing: Interpreting What That Number Means.Missouri medicineArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While postmortem (PM) toxicology results provide valuable information towards ascertaining both the cause and manner of death in coronial cases, there are also significant difficulties associated with the interpretation of PM drug levels. Such difficulties are influenced by several pharmacokinetic and pharmacodynamic factors including PM redistribution, diffusion, site-to-site variability in drug levels, different drug properties and metabolism, bacterial activity, genetic polymorphisms, tolerance, resuscitation efforts, underlying conditions, and the toxicity profile of cases (i.e. single- or mixed-drug toxicity). A large body of research has been dedicated for better understanding and even quantifying the influence of these factors on PM drug levels. For example, several investigative matrices have been developed as potential indicators of PM redistribution, but they have limited practical value. Reference tables of clinically relevant therapeutic, toxic, and potentially fatal drug concentrations have also been compiled, but these unfortunately do not provide reliable reference values for PM toxicology. More recent research has focused on developing databases of peripheral PM drug levels for a variety of case-types to increase transferability to real-life cases and improve interpretations. Changes to drug levels after death are inevitable and unavoidable. As such, guidelines and practices will continue to evolve as we further our understanding of such phenomena.
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