Evidence map›Paper›PMID 3885010›Full record

ArticleMolecular and cellular biology1985

Regulation of CDC9, the Saccharomyces cerevisiae gene that encodes DNA ligase.

T A Peterson, L Prakash, S Prakash, M A Osley, S I Reed

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular biology, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 102 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Identification and purification of a factor that binds to the Mlu I cell cycle box of yeast DNA replication genes.Proceedings of the National Academy of Sciences of the United States of America · 1991
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

T A Peterson
L Prakash
S Prakash
M A Osley
S I Reed
University of California, Santa Barbara · US

Funding

Transcription-coupled DNA repair in yeastR01CA035035 · NCI · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI PRAKASH, SATYA · 1985 to 2008
$1.7M
REPAIR OF DNA DAMAGED BY UV IRRADIATION IN YEASTR01GM019261 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI PRAKASH, LOUISE · 1985 to 2003
$1.4M
EXCISION REPAIR OF UV IRRADIATED DNA IN YEASTR37CA035035 · NCI · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI PRAKASH, SATYA · 1993 to 2001
$682k
NCI NIH HHS CA35035NIGMS NIH HHS GM07621NIGMS NIH HHS GM19261
6 · The paper itself

Abstract

We have cloned CDC9, the structural gene for Saccharomyces cerevisiae DNA ligase, and investigated its transcriptional regulation both as a function of cell cycle stage and after UV irradiation. The steady-state level of DNA ligase mRNA increases at least fourfold in late G1, after the completion of start but before S phase. This high level of CDC9 mRNA then decays with an apparent half-life of ca. 20 min and remains at a low basal level throughout the rest of the cell cycle. The accumulation of CDC9 mRNA in late G1 is dependent upon the completion of start but not the CDC7 and CDC8 functions. Exposure of cells to UV light elicits an eightfold increase in DNA ligase mRNA levels.

Indexed as

Gene Expression RegulationTranscription, GeneticCell CycleDNA LigasesDNA RepairGenesGenes, FungalMethyl MethanesulfonatePeriodicityPolynucleotide LigasesSaccharomyces cerevisiaeUltraviolet RaysDNA LigasesMethyl MethanesulfonatePolynucleotide Ligases

Identifiers

PMID3885010
PMCPMC366697
OpenAlexW1793009834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.