ArticlePlant physiology2024
CDPK5 and CDPK13 play key roles in acclimation to low oxygen through the control of RBOH-mediated ROS production in rice.
Article in Plant physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Integrative Physiological, Transcriptomic, and Functional Analysis Reveals a Positive Contribution ofGenes · 2026Article
- Phosphorylation of VpCAMTA3 by VpCDPK13 enhances cold tolerance in grapevine.Horticulture research · 2026Article
- Rhizosphere Reactive Oxygen Species: Detection Methods, Distribution Characteristics, Production Mechanisms, and Environmental Effects.Current issues in molecular biology · 2026Review
- Molecular and hormonal regulation of plant responses to waterlogging stress: From fundamental mechanisms to potential strategies for engineering crop tolerance.Plant communications · 2026Review
- Linking Superoxide Production and Scavenging in Plant Development.Plant, cell & environment · 2026Review
- From recognition to response: integrated signaling pathways determining pollen acceptance and rejection in Brassicaceae.The New phytologist · 2026Review
- Waterlogging tolerance in pigeonpea: current understanding of physiological responses, genetic resources, and genomic prospects.Frontiers in plant science · 2026Review
- Role of AtCPK5 and AtCPK6 in the regulation of the plant immune response triggered by rhamnolipids in Arabidopsis.PloS one · 2026Article
- Roles of ROS and NO in Plant Responses to Individual and Combined Salt Stress and Waterlogging.Antioxidants (Basel, Switzerland) · 2025Review
- Loss of calcium-dependent protein kinases OsCPK5 and OsCPK13 leads to NLR-dependent resistance in rice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Classification of Calcium-Dependent Protein Kinases and Their Transcriptional Response to Abiotic Stresses in HalophytePlants (Basel, Switzerland) · 2025Article
- Hypoxia as challenge and opportunity: From cells to crops, to synthetic biology.Plant physiology · 2024Article
- Rooting for survival: OsCDPK5 and OsCDPK13 are crucial for rice acclimation to low-oxygen conditions.Plant physiology · 2024Article
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Authors and funding
10 authors.
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Abstract
CALCIUM-DEPENDENT PROTEIN KINASE (CDPK) stimulates reactive oxygen species (ROS)-dependent signaling by activating RESPIRATORY BURST OXIDASE HOMOLOG (RBOH). The lysigenous aerenchyma is a gas space created by cortical cell death that facilitates oxygen diffusion from the shoot to the root tips. Previously, we showed that RBOHH is indispensable for the induction of aerenchyma formation in rice (Oryza sativa) roots under low-oxygen conditions. Here, we showed that CDPK5 and CDPK13 localize to the plasma membrane where RBOHH functions. Mutation analysis of the serine at residues 92 and 107 of RBOHH revealed that these residues are required for CDPK5- and CDPK13-mediated activation of ROS production. The requirement of Ca2+ for CDPK5 and CDPK13 function was confirmed using in vitro kinase assays. CRISPR/Cas9-based mutagenesis of CDPK5 and/or CDPK13 revealed that the double knockout almost completely suppressed inducible aerenchyma formation, whereas the effects were limited in the single knockout of either CDPK5 or CDPK13. Interestingly, the double knockout almost suppressed the induction of adventitious root formation, which is widely conserved in vascular plants, under low-oxygen conditions. Our results suggest that CDPKs are essential for the acclimation of rice to low-oxygen conditions and also for many other plant species conserving CDPK-targeted phosphorylation sites in RBOH homologs.
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