Evidence map›Paper›PMID 38849980›Full record

ArticleBrain and behavior2024

Associations between atypical intracortical myelin content and neuropsychological functions in middle to older aged adults with ASD.

Jiwandeep S Kohli, Annika C Linke, Ian A Martindale, Molly Wilkinson, Mikaela K Kinnear, Alan J Lincoln, Janice Hau, Ian Shryock, Vinton Omaleki, Kalekirstos Alemu and 4 more

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In one paragraph

Article in Brain and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jiwandeep S KohliBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, California, USA.ORCID 0000-0002-1704-155X
Annika C LinkeBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, California, USA.
Ian A MartindaleBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, California, USA.
Molly WilkinsonBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, California, USA.
Mikaela K KinnearBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, California, USA.
Alan J LincolnCalifornia School of Professional Psychology, Alliant International University, San Diego, California, USA.
Janice HauBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, California, USA.ORCID 0000-0002-6919-1971
Ian ShryockBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, California, USA.
Vinton OmalekiBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, California, USA.
Kalekirstos AlemuBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, California, USA.
Stephanie PedrahitaBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, California, USA.
Inna FishmanBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, California, USA.
Ralph-Axel MüllerBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, California, USA.
Ruth A CarperBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, California, USA.

Funding

Autism Speaks Pre-Doctoral Fellowship (JSK) 11736National Institutes of Health (RAC, RAM) R01-MH103494
6 · The paper itself

Abstract

introductionIn vivo myeloarchitectonic mapping based on Magnetic Resonance Imaging (MRI) provides a unique view of gray matter myelin content and offers information complementary to other morphological indices commonly employed in studies of autism spectrum disorder (ASD). The current study sought to determine if intracortical myelin content (MC) and its age-related trajectories differ between middle aged to older adults with ASD and age-matched typical comparison participants.

methodsData from 30 individuals with ASD and 36 age-matched typical comparison participants aged 40-70 years were analyzed. Given substantial heterogeneity in both etiology and outcomes in ASD, we utilized both group-level and subject-level analysis approaches to test for signs of atypical intracortical MC as estimated by T1w/T2w ratio.

resultsGroup-level analyses showed no significant differences in average T1w/T2w ratio or its associations with age between groups, but revealed significant positive main effects of age bilaterally, with T1w/T2w ratio increasing with age across much of the cortex. In subject-level analyses, participants were classified into subgroups based on presence or absence of clusters of aberrant T1w/T2w ratio, and lower neuropsychological function was observed in the ASD subgroup with atypically high T1w/T2w ratio in spatially heterogeneous cortical regions. These differences were observed across several neuropsychological domains, including overall intellectual functioning, processing speed, and aspects of executive function.

conclusionsThe group-level and subject-level approaches employed here demonstrate the value of examining inter-individual variability and provide important preliminary insights into relationships between brain structure and cognition in the second half of the lifespan in ASD, suggesting shared factors contributing to atypical intracortical myelin content and poorer cognitive outcomes for a subset of middle aged to older autistic adults. These atypicalities likely reflect diverse histories of neurodevelopmental deficits, and possible compensatory changes, compounded by processes of aging, and may serve as useful markers of vulnerability to further cognitive decline in older adults with ASD.

Indexed as

Autism Spectrum DisorderMagnetic Resonance ImagingMyelin SheathAdultAgedAgingCerebral CortexFemaleHumansMaleMiddle AgedNeuropsychological Testsagingautism spectrum disordercortexmyelinneuroimagingneuropsychology

Identifiers

PMID38849980
PMCPMC11161394

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.