ArticleBMC psychiatry2024
Disrupted default mode network connectivity in bipolar disorder: a resting-state fMRI study.
Article in BMC psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pharmaco-psychiatry and gut microbiome: a systematic review of effects of psychotropic drugs for bipolar disorder.Microbiology (Reading, England) · 2025Pooled it
- [Dynamic alterations in regional brain activity associated with bipolar disorder and smoking status].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Functional alterations of the medial frontal gyrus as candidate biomarkers for resilience in major depressive disorder.BMC psychiatry · 2026Article
- Molecular and Neuroimaging Correlates of Bipolar Disorder: Linking Inflammation, Mitochondria, and Brain Circuitry.International journal of molecular sciences · 2026Review
- The neurobiological basis of the awe experience in affective disorders: an exploratory EEG study.Frontiers in systems neuroscience · 2026Article
- Genetic variants in GRIN2B and NTRK2 on the etiology and treatment response to valproate and lithium in patients with bipolar disorder.Pharmacological reports : PR · 2025Article
- Alterations of brain white matter network topological properties in overt hypothyroidism.Endocrine connections · 2025Article
- Neuroimaging Changes in the Sensorimotor Network and Visual Network in Bipolar Disorder and Their Relationship with Genetic Characteristics.Biomedicines · 2025Article
- Lactate flux dysfunction in patients with bipolar disorder: preliminary insights from ultra-high field 7T MRSI during task and rest.Frontiers in neuroscience · 2025Article
- Neurocognitive function across different phases of bipolar disorder: an evaluation using the B-CATS.Frontiers in psychiatry · 2025Article
- Fractional Amplitude of Low-Frequency Fluctuations and Regional Homogeneity Analyses Revealed Altered Local Spontaneous Neural Activities in Ankylosing Spondylitis.Journal of pain research · 2025Article
- The Role of Temperament Traits in Bipolar Disorder: Neuroimaging Study.Depression and anxiety · 2025Article
- A brain structure learning-guided multi-view graph representation learning for brain network analysis.Quantitative imaging in medicine and surgery · 2024Article
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6 authors.
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Abstract
backgroundTheoretical and empirical evidence indicates the critical role of the default mode network (DMN) in the pathophysiology of the bipolar disorder (BD). This study aims to identify the specific brain regions of the DMN that is impaired in patients with BD.
methodsA total of 56 patients with BD and 71 healthy controls (HC) underwent resting-state functional magnetic resonance imaging. Three commonly used functional indices, i.e., fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), and degree centrality (DC), were utilized to identify the brain region showing abnormal spontaneous brain activity in patients with BD. Then, this region served as the seed region for resting-state functional connectivity (rsFC) analysis.
resultsCompared to the HC group, the BD group showed reduced fALFF, ReHo, and DC values in the left precuneus. Moreover, patients exhibited decreased rsFCs within the left precuneus and between the left precuneus and the medial prefrontal cortex. Additionally, there was diminished negative connectivity between the left precuneus and the left putamen, extending to the left insula (putamen/insula). The abnormalities in DMN functional connectivity were confirmed through various analysis strategies.
conclusionsOur findings provide convergent evidence for the abnormalities in the DMN, particularly located in the left precuneus. Decreased functional connectivity within the DMN and the reduced anticorrelation between the DMN and the salience network are found in patients with BD. These findings suggest that the DMN is a key aspect for understanding the neural basis of BD, and the altered functional patterns of DMN may be a potential candidate biomarker for diagnosis of BD.
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