Evidence map›Paper›PMID 38849741›Full record

ArticleBMC cancer2024

Diagnostic accuracy and clinical value of [68Ga]Ga-FAPI-46 PET/CT for staging patients with ovarian cancer: study protocol for a prospective clinical trial.

Morten Bentestuen, Morten Ladekarl, Aage Knudsen, Helle D Zacho

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05903807 ([68Ga]Ga-FAPI-46 PET/CT), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05903807 phase2terminatednot on this map

[68Ga]Ga-FAPI-46 PET/CT: The Diagnostic Accuracy for Primary Staging and Re-staging of Patients With Ovarian Cancer

TypeinterventionalSponsorAalborg University HospitalRan2023 to 2026Enrolled20ConditionsOvarian CancerArms68Ga-FAPi-46
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Safety of [Clinical physiology and functional imaging · 2026
    Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Morten BentestuenDepartment of Nuclear Medicine and Clinical Cancer Research Center, Aalborg University Hospital, Hobrovej 18- 22, Aalborg, DK-9000, Denmark. m.bentestuen@rn.dk.ORCID https://orcid.org/0000-0001-6115-0967
Morten LadekarlDepartment of Oncology and Clinical Cancer Research Center, Aalborg University Hospital, Hobrovej 18-22, Aalborg, DK- 9000, Denmark.ORCID https://orcid.org/0000-0002-0182-1228
Aage KnudsenDepartment of Gynecology and Obstetrics, Aalborg University Hospital, Reberbansgade 15, Aalborg, DK-9000, Denmark.
Helle D ZachoDepartment of Nuclear Medicine and Clinical Cancer Research Center, Aalborg University Hospital, Hobrovej 18- 22, Aalborg, DK-9000, Denmark.ORCID https://orcid.org/0000-0001-9089-288X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background[ METHODS AND

designFifty consecutive ovarian cancer patients will be recruited from Aalborg University Hospital, Denmark. This study will be a single-center, prospective, exploratory clinical trial that adheres to the standards for reporting diagnostic accuracy studies (STARD). This study will be conducted under continuous Good Clinical Practice monitoring. The eligibility criteria for patients are as follows: (1) biopsy verified newly diagnosed ovarian cancer or a high risk of ovarian cancer and referred for primary staging with [ DISCUSSION: To our knowledge, this trial represents the largest, most extensive, and most meticulous prospective FAPI PET study conducted in patients with ovarian cancer thus far. This study aims to obtain a reliable estimation of the diagnostic accuracy of [

trial registrationclinicaltrials.gov: NCT05903807, 2nd June 2023; and euclinicaltrials.eu EU CT Number: 2023-505938-98-00, authorized 11th September 2023.

Indexed as

Fluorodeoxyglucose F18Gallium RadioisotopesNeoplasm StagingOvarian NeoplasmsPositron Emission Tomography Computed TomographyAdultAgedClinical Trials as TopicFemaleHumansMiddle AgedProspective StudiesQuinolinesRadiopharmaceuticals68Ga-FAPIFluorodeoxyglucose F18Gallium RadioisotopesQuinolinesRadiopharmaceuticals[68Ga]Ga-FAPI-46FAPIFibroblast activation protein inhibitorOvarian cancerPETPositron emission tomography

Identifiers

PMID38849741
PMCPMC11157941

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.