Evidence map›Paper›PMID 38849734›Full record

Trial reportBMC anesthesiology2024

Intravenous ibuprofen versus ketorolac for perioperative pain control in open abdominal hysterectomy: a randomized controlled trial.

Sarah Amin, Ahmed Hasanin, Ola A Attia, Maha Mostafa, Nashwa S Elzayat, Mona Elsherbiny, Amany A Eissa

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05610384 (Intravenous Ibuprofen Versus Ketorolac for Perioperative Pain Control After Open Hysterectomy), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05610384 nacompletednot on this map

Intravenous Ibuprofen Versus Ketorolac for Perioperative Pain Control After Open Hysterectomy: a Randomized Controlled Trial

TypeinterventionalSponsorCairo UniversityRan2022 to 2023Enrolled100ConditionsPostoperative Pain, HysterectomyArmsKetorolac Injectable Solution, Ibuprofen 800 mg
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah AminDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Ahmed HasaninDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt. ahmedmohamedhasanin@gmail.com.
Ola A AttiaDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Maha MostafaDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Nashwa S ElzayatDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Mona ElsherbinyDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Amany A EissaDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to compare the analgesic effects of intravenous ibuprofen to ketorolac after open abdominal hysterectomy.

methodsThis randomized double-blinded controlled trial included adult women scheduled for elective open abdominal hysterectomy. Participants were randomized to receive either 30 mg ketorolac (n = 50) or 800 mg ibuprofen (n = 50) preoperatively, then every 8 h postoperatively for 24 h. All participants received paracetamol 1 gm/6 h. Rescue analgesic was given if the visual analogue scale (VAS) for pain assessment was > 3. The primary outcome was the mean postoperative dynamic VAS during the first 24 h. Secondary outcomes were static VAS, intraoperative fentanyl consumption, postoperative morphine consumption, time to independent movement, and patient's satisfaction.

resultsForty-six patients in the ibuprofen group and fifty patients in the ketorolac group were analyzed. The 24-h dynamic and static VAS were similar in the two groups. The median (quartiles) dynamic VAS was 1.1 (0.9, 1.9) in the ibuprofen group versus 1.0 (0.7, 1.3) in the ketorolac group, P-value = 0.116; and the median (quartiles) static VAS was 0.9 (0.6, 1.3) in the ibuprofen group versus 0.7 (0.4, 1.1) in the ketorolac group, P-value = 0.113. The intra- and postoperative analgesic requirements were also similar in the two groups. However, patient satisfaction was slightly higher in the ketorolac group than that in the ibuprofen group (median [quartiles]: 6 [5, 7] versus 5 [4, 7], respectively), P-value: 0.009.

conclusionThe two drugs, intravenous ibuprofen and ketorolac produced similar analgesic profile in patients undergoing open abdominal hysterectomy receiving multimodal analgesic regimen. NCT05610384, Date of registration: 09/11/2022 CLINICAL

trial registrationClinicalTrials.gov Identifier: NCT05610384. https://clinicaltrials.gov/ct2/show/NCT05610384.

Indexed as

Anti-Inflammatory Agents, Non-SteroidalHysterectomyIbuprofenKetorolacPostoperative PainAdministration, IntravenousAdultAnalgesics, Non-NarcoticDouble-Blind MethodFemaleHumansMiddle AgedPain MeasurementPatient SatisfactionAnalgesics, Non-NarcoticAnti-Inflammatory Agents, Non-SteroidalIbuprofenKetorolacIbuprofenKetorolacOpen hysterectomyPostoperative painVisual analogue scale

Identifiers

PMID38849734
PMCPMC11157756

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.