ArticleCommunications biology2024
Fronto-thalamic networks and the left ventral thalamic nuclei play a key role in aphasia after thalamic stroke.
Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Neuroimaging Correlates of Post-Stroke Pain After Ischemic Stroke: Secondary Analysis of the INSPiRE-TMS Trial.Human brain mapping · 2026Article
- Who Falls After a Stroke? Evidence From a Prospective Stroke Cohort.European journal of neurology · 2026Article
- Acute-Phase Machine Learning Prediction of 12-Month Aphasia and Discourse Recovery.medRxiv : the preprint server for health sciences · 2026Article
- Object Naming After Thalamic Damage: Evidence From a Large-Scale, Chronic-Phase Study of Left Hemisphere Stroke Survivors.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Phase Angle Is a Potential Novel Early Marker for Sarcopenia and Cognitive Impairment in the General Population.Journal of cachexia, sarcopenia and muscle · 2025Article
- Functional network reorganization and memory impairment in unruptured brain arteriovenous malformations.Frontiers in neuroscience · 2025Article
- Thalamic disconnection from prefrontal cognitive control networks contributes to thalamic aphasia.Brain communications · 2025Article
- Characteristics and prognosis of language impairment in subcortical aphasia of acute stroke patients.Frontiers in neurology · 2025Article
- Redefining language networks: connectivity beyond localised regions.Brain structure & function · 2024Article
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Authors and funding
14 authors.
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Abstract
Thalamic aphasia results from focal thalamic lesions that cause dysfunction of remote but functionally connected cortical areas due to language network perturbation. However, specific local and network-level neural substrates of thalamic aphasia remain incompletely understood. Using lesion symptom mapping, we demonstrate that lesions in the left ventrolateral and ventral anterior thalamic nucleus are most strongly associated with aphasia in general and with impaired semantic and phonemic fluency and complex comprehension in particular. Lesion network mapping (using a normative connectome based on fMRI data from 1000 healthy individuals) reveals a Thalamic aphasia network encompassing widespread left-hemispheric cerebral connections, with Broca's area showing the strongest associations, followed by the superior and middle frontal gyri, precentral and paracingulate gyri, and globus pallidus. Our results imply the critical involvement of the left ventrolateral and left ventral anterior thalamic nuclei in engaging left frontal cortical areas, especially Broca's area, during language processing.
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