Evidence map›Paper›PMID 38849462›Full record

ArticleInternational journal of obesity (2005)2024

Associations between obesity, a composite risk score for probable long COVID, and sleep problems in SARS-CoV-2 vaccinated individuals.

Pei Xue, Ilona Merikanto, Eva A Delale, Adrijana Bjelajac, Juliana Yordanova, Rachel N Y Chan, Maria Korman, Sérgio A Mota-Rolim, Anne-Marie Landtblom, Kentaro Matsui and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of obesity (2005), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Pei XueDepartment of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. pei.xue@uu.se.
Ilona MerikantoResearch Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-1222-6678
Eva A DelaleInstitute for Anthropological Research, Zagreb, Croatia.
Adrijana BjelajacInstitute for Medical Research and Occupational Health, Zagreb, Croatia.ORCID 0000-0003-0547-0047
Juliana YordanovaInstitute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Rachel N Y ChanLi Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Maria KormanDepartment of Occupational Therapy, Faculty of Health Sciences, Ariel University, Ariel, Israel.
Sérgio A Mota-RolimBrain Institute, Federal University of Rio Grande do Norte, Federal, Brazil.
Anne-Marie LandtblomDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Kentaro MatsuiDepartment of Clinical Laboratory, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.ORCID 0000-0003-4538-5381
Catia ReisInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.ORCID 0000-0001-6585-3993
Thomas PenzelSleep Medicine Center, Charite University Hospital Berlin, Berlin, Germany.ORCID 0000-0002-4304-0112
Yuichi InoueDepartment of Somnology, Tokyo Medical University, Tokyo, Japan.
Michael R NadorffDepartment of Psychology, Mississippi State University, Mississippi, MI, USA.
Brigitte HolzingerMedical University of Vienna, Postgraduate, Schlafcoaching, Vienna, Austria.
Charles M MorinCentre de recherche CERVO/Brain Research Center, École de psychologie, Université Laval, Quebec City, Quebec, Canada.ORCID 0000-0002-8649-8895
Colin A EspieSleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, QC, UK.
Giuseppe PlazziIRCCS Istituto Delle Scienze Neurologiche di Bologna, Bologna, Italy.
Luigi De GennaroDepartment of Psychology, Sapienza University of Rome, Roma, Lazio, Italy.ORCID 0000-0003-3613-6631
Frances ChungDepartment of Anesthesiology and Pain Medicine, University Health Network, University of Toronto, Toronto, ON, Canada.
Bjørn BjorvatnDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Yun Kwok WingLi Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-5745-5474
Yves DauvilliersSleep-Wake Disorders Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU, Montpellier, France.
Markku PartinenDepartment of Clinical Neurosciences, University of Helsinki Clinicum Unit, Helsinki, Finland.
Christian BenedictDepartment of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. christian.benedict@uu.se.ORCID 0000-0002-8911-4068

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreliminary data suggests that obesity might hasten the decline in mRNA vaccine-induced immunity against SARS-CoV-2. However, whether this renders individuals with obesity more susceptible to long COVID symptoms post-vaccination remains uncertain. Given sleep's critical role in immunity, exploring the associations between obesity, probable long COVID symptoms, and sleep disturbances is essential.

methodsWe analyzed data from a survey of 5919 adults aged 18 to 89, all of whom received two SARS-CoV-2 mRNA vaccinations. Participants were categorized into normal weight, overweight, and obesity groups based on ethnicity-specific BMI cutoffs. The probability of long COVID was evaluated using the Post-Acute Sequelae of SARS-CoV-2 (PASC) score, as our survey did not permit confirmation of acute SARS-CoV-2 infection through methods such as antibody testing. Additionally, sleep patterns were assessed through questionnaires.

resultsParticipants with obesity exhibited a significantly higher adjusted odds ratio (OR) of having a PASC score of 12 or higher, indicative of probable long COVID in our study, compared to those with normal weight (OR: 1.55, 95% CI: 1.05, 2.28). No significant difference was observed for overweight individuals (OR: 0.92 [95% CI: 0.63, 1.33]). Both obesity and probable long COVID were associated with increased odds of experiencing a heightened sleep burden, such as the presence of obstructive sleep apnea or insomnia (P < 0.001). However, no significant interaction between BMI and probable long COVID status was found.

conclusionsEven post-vaccination, individuals with obesity may encounter a heightened risk of experiencing prolonged COVID-19 symptoms. However, confirming our observations necessitates comprehensive studies incorporating rigorous COVID infection testing, such as antibody assays - unavailable in our anonymous survey. Additionally, it is noteworthy that the correlation between probable long COVID and sleep disturbances appears to be independent of BMI.

Indexed as

COVID-19COVID-19 VaccinesObesitySARS-CoV-2Sleep Wake DisordersAdolescentAdultAgedAged, 80 and overBody Mass IndexFemaleHumansMaleMiddle AgedPost-Acute COVID-19 SyndromeRisk FactorsCOVID-19 Vaccines

Identifiers

PMID38849462
PMCPMC11347373

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.