Evidence map›Paper›PMID 38849415›Full record

ArticleScientific reports2024

A genome-wide association study reveals a polygenic architecture of speech-in-noise deficits in individuals with self-reported normal hearing.

Ishan Sunilkumar Bhatt, Juan Antonio Raygoza Garay, Srividya Grama Bhagavan, Valerie Ingalls, Raquel Dias, Ali Torkamani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ishan Sunilkumar BhattDepartment of Communication Sciences and Disorders, University of Iowa, 250 Hawkins Dr, Iowa City, IA, 52242, USA. Ishan-Bhatt@uiowa.edu.
Juan Antonio Raygoza GarayDepartment of Communication Sciences and Disorders, University of Iowa, 250 Hawkins Dr, Iowa City, IA, 52242, USA.
Srividya Grama BhagavanDepartment of Communication Sciences and Disorders, University of Iowa, 250 Hawkins Dr, Iowa City, IA, 52242, USA.
Valerie IngallsDepartment of Communication Sciences and Disorders, University of Iowa, 250 Hawkins Dr, Iowa City, IA, 52242, USA.
Raquel DiasDepartment of Microbiology and Cell Science, University of Florida, Gainesville, FL, 32608, USA.
Ali TorkamaniDepartment of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, 92037, USA.

Funding

Tinnitus: Audiological measures and genetic susceptibilityR21DC016704 · NIDCD · UNIVERSITY OF IOWA · PI BHATT, ISHAN SUNILKUMAR · 2019 to 2021
$439k
NIDCD NIH HHS R21 DC016704NIDCD NIH HHS R21DC016704-01A1
6 · The paper itself

Abstract

Speech-in-noise (SIN) perception is a primary complaint of individuals with audiometric hearing loss. SIN performance varies drastically, even among individuals with normal hearing. The present genome-wide association study (GWAS) investigated the genetic basis of SIN deficits in individuals with self-reported normal hearing in quiet situations. GWAS was performed on 279,911 individuals from the UB Biobank cohort, with 58,847 reporting SIN deficits despite reporting normal hearing in quiet. GWAS identified 996 single nucleotide polymorphisms (SNPs), achieving significance (p < 5*10

Indexed as

Genome-Wide Association StudyMultifactorial InheritanceNoisePolymorphism, Single NucleotideSpeech PerceptionAdultAgedFemaleHearingHumansMaleMiddle AgedSelf ReportYoung AdultAge-related hearing difficulty in noiseAudiogramDistortion-product otoacoustic emissionsExtended-high frequencyGenome-wide associationGlutamate metabotropic receptor 3Glutamate metabotropic receptor 7Hearing thresholdsHidden hearing lossMicrotubule-associated protein tauSelf-reported speech perceptionSpeech-in-noise deficits

Identifiers

PMID38849415
PMCPMC11161523

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.