Evidence map›Paper›PMID 38848592›Full record

ReviewAnnual review of virology2024

Embracing Complexity: What Novel Sequencing Methods Are Teaching Us About Herpesvirus Genomic Diversity.

Alejandro Ortigas-Vasquez, Moriah Szpara

Abstract readReview
In one paragraph

Review in Annual review of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alejandro Ortigas-VasquezDepartments of Biology and of Biochemistry and Molecular Biology; Center for Infectious Disease Dynamics; and Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, USA; email: moriah@psu.edu.
Moriah SzparaDepartments of Biology and of Biochemistry and Molecular Biology; Center for Infectious Disease Dynamics; and Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, USA; email: moriah@psu.edu.

Funding

The impact of viral genomic variation on neonatal disease outcomesR01AI163217 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI MORIAH SZPARA · 2022 to 2026
$3.2M
Forward genetic prediction and testing of virulence loci in herpes simplex virus 1R01AI132692 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI SZPARA, MORIAH · 2018 to 2022
$2.3M
US-UK Collab: The consequences of transmissible vaccines on disease ecology and pathogen evolution: Marek's disease virus as a case studyR01GM140459 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI KENNEDY, DAVID · 2020 to 2024
$1.7M
Using experimental evolution to probe herpesvirus adaptation to neurons, fibroblasts, & interferon signalingR21AI159480 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI SZPARA, MORIAH · 2022 to 2023
$433k
NIAID NIH HHS R01 AI132692NIAID NIH HHS R01 AI163217NIAID NIH HHS R21 AI159480NIGMS NIH HHS R01 GM140459
6 · The paper itself

Abstract

The arrival of novel sequencing technologies throughout the past two decades has led to a paradigm shift in our understanding of herpesvirus genomic diversity. Previously, herpesviruses were seen as a family of DNA viruses with low genomic diversity. However, a growing body of evidence now suggests that herpesviruses exist as dynamic populations that possess standing variation and evolve at much faster rates than previously assumed. In this review, we explore how strategies such as deep sequencing, long-read sequencing, and haplotype reconstruction are allowing scientists to dissect the genomic composition of herpesvirus populations. We also discuss the challenges that need to be addressed before a detailed picture of herpesvirus diversity can emerge.

Indexed as

Genetic VariationGenome, ViralHerpesviridaeHigh-Throughput Nucleotide SequencingAnimalsEvolution, MolecularGenomicsHaplotypesHerpesviridae InfectionsHumansPhylogenySequence Analysis, DNAdeep sequencinggenomicshaplotype reconstructionherpesviruseslong-read sequencingquasispecies

Identifiers

PMID38848592
PMCPMC12574701

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.