Evidence map›Paper›PMID 38848521›Full record

Trial reportJCO precision oncology2024

Serial Cell-Free DNA Sequencing in

Noura J Choudhury, Hyung Jun Woo, Monica Chen, Ronak Shah, Mark Donoghue, Michael Berger, Alexander Drilon

Abstract readClinical Trial, Phase II
In one paragraph

Trial report in JCO precision oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Noura J ChoudhuryDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-5980-4973
Hyung Jun WooCenter for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0003-3220-2064
Monica ChenDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-7485-2463
Ronak ShahCenter for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-9042-6213
Mark DonoghueCenter for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.
Michael BergerCenter for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0003-3882-5000
Alexander DrilonDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-6806-9061

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Integration of Imaging and Circulating Plasma Cell-Free DNA Sequencing Using MSK-ACCESS to Monitor Treatment Response and Predict Progression in Patients With Multiple Cancers on Targeted TherapyR01CA273224 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Michael F. Berger, Alexander Drilon · 2022 to 2026
$3.6M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA273224
6 · The paper itself

Abstract

purposePatients with metastatic

methodsIn patients with

resultsTwelve patients were included, with best response as partial response (n = 9, 75%), stable disease (n = 2, 17%), and progressive disease (PD; n = 1, 8%). A

conclusionSerial cfDNA monitoring may complement radiographic assessments as determinants of response and resistance to entrectinib in

Indexed as

BenzamidesCarcinoma, Non-Small-Cell LungIndazolesLung NeoplasmsProtein-Tyrosine KinasesProto-Oncogene ProteinsAdultAgedCell-Free Nucleic AcidsFemaleHumansMaleMiddle AgedOncogene Proteins, FusionSequence Analysis, DNABenzamidesCell-Free Nucleic AcidsentrectinibIndazolesOncogene Proteins, FusionProtein-Tyrosine KinasesProto-Oncogene ProteinsROS1 protein, human

Identifiers

PMID38848521
PMCPMC11545664

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.