ArticleScience advances2024
Epigenetic predictors of species maximum life span and other life-history traits in mammals.
Abstract read
In one paragraph
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Prospects of multipurpose biomonitoring for fisheries assessment based on environmental nucleic acids.Journal of fish biology · 2026Review
- Biological aging clocks in health and disease.Nature medicine · 2026Review
- The potential of methylation signal detection in eDNA toward functional ecological monitoring.Communications biology · 2026Review
- Article
- Parental kinship influences global methylation and epigenetic age estimation in Peromyscus.Genetics · 2026Article
- Identification and validation of circadian rhythm and astrocyte-associated diagnostic and therapeutic model for cirrhosis encephalopathy patients via integrative bioinformatic pipelines andFrontiers in neuroscience · 2026Article
- Salivary DNA methylation and pubertal development in adolescents.Scientific reports · 2025Article
- Global, regional, and national burden of aortic aneurysm disease and its attributable risk factor, 1990-2021: a systematic analysis for the global burden of disease study 2021.Internal and emergency medicine · 2025Article
- Unlocking longevity through the comparative biology of aging.Nature aging · 2025Review
- Epigenetic clocks and DNA methylation biomarkers of brain health and disease.Nature reviews. Neurology · 2025Review
- The burden of intracerebral hemorrhage attributable to ambient particulate matter pollution in five Asian countries: a 32-year comparative analysis.BMC public health · 2025Article
- Biomarkers of aging: from molecules and surrogates to physiology and function.Physiological reviews · 2025Review
- Potential Epigenetic Impacts of Phytochemicals on Ruminant Health and Production: Connecting Lines of Evidence.Animals : an open access journal from MDPI · 2025Review
- CMImpute: cross-species and tissue imputation of species-level DNA methylation samples across mammalian species.Genome biology · 2025Article
- Epigenetic ageing clocks: statistical methods and emerging computational challenges.Nature reviews. Genetics · 2025Review
- Enhancing epigenetic aging clocks in cetaceans: accurate age estimations in small endangered delphinids, killer whales, pilot whales, belugas, humpbacks, and bowhead whales.Scientific reports · 2025Article
- Epigenetic pharmacology in aging: from mechanisms to therapies for age-related disorders.Frontiers in pharmacology · 2025Review
- Article
- Epigenetic clocks and programmatic aging.Ageing research reviews · 2024Review
- Universal prediction of vertebrate species age at maturity.Communications biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Caesar Z LiDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-3907-7983
Amin HaghaniDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-6052-8793
Qi YanDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-4418-123X
Ake T LuDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-2866-7961
Joshua ZhangDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-4488-1175
Zhe FeiDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-9568-2857
Jason ErnstDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-4026-7853
X William YangCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-3705-7935
Vadim N GladyshevDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0372-7016
Todd R RobeckZoological Operations, SeaWorld Parks and Entertainment Inc., Orlando, FL, USA.ORCID 0000-0001-8573-5070
Andreas S ChavezDepartment of Evolution, Ecology and Organismal Biology, The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-4559-9091
Joseph A CookDepartment of Biology and Museum of Southwestern Biology, University of New Mexico, Albuquerque, NM, USA.ORCID 0000-0003-3985-0670
Jonathan L DunnumDepartment of Biology and Museum of Southwestern Biology, University of New Mexico, Albuquerque, NM, USA.ORCID 0000-0001-7868-3719
Ken RajAltos Labs, Cambridge, UK.ORCID 0000-0002-3744-265X
Andrei SeluanovDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.ORCID 0000-0003-3400-538X
Vera GorbunovaDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.ORCID 0000-0001-8979-0333
Steve HorvathDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-4110-3589
Funding
The role of hyaluronan in longevity and cancer resistance of longest-lived rodentP01AG047200 · NIA · UNIVERSITY OF ROCHESTER · PI Vadim N. Gladyshev · 2014 to 2026
$36.9MSomatic Activation of Retrotransposition: A New Molecular Mechanism of Aging?P01AG051449 · NIA · BROWN UNIVERSITY · PI John M Sedivy · 2016 to 2026
$30.4MThe role of SIRT6 posttranslational modifications in aging and genome stability. Supplement: Testing SIRT6 activators as potential Alzheimer's disease therapy.R01AG027237 · NIA · UNIVERSITY OF ROCHESTER · PI Vera Gorbunova · 2006 to 2026
$6.2MRegulation of epigenome stability by SIRT6 during aging. Supplement: Does centenarian variant of SIRT6 or bowhead whale SIRT6 confer protection from Alzheimer's disease?R37AG046320 · NIA · UNIVERSITY OF ROCHESTER · PI Andrei Seluanov · 2019 to 2026
$4.7MRegulation of genome stability by SITR6R01AG046320 · NIA · UNIVERSITY OF ROCHESTER · PI SELUANOV, ANDREI · 2014 to 2018
$1.9MThe skin of naked mole rats as a model for scar-free wound healingR33AR078093 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BOTCHKAREV, VLADIMIR A, GORBUNOVA, VERA · 2023 to 2023
$406kNIAMS NIH HHS R33 AR078093NIA NIH HHS P01 AG047200NIA NIH HHS P01 AG051449NIA NIH HHS R01 AG027237NIA NIH HHS R01 AG046320NIA NIH HHS R37 AG046320
Abstract
By analyzing 15,000 samples from 348 mammalian species, we derive DNA methylation (DNAm) predictors of maximum life span (
Indexed as
DNA MethylationEpigenesis, GeneticLongevityMammalsAnimalsFemaleHumansLife History TraitsMaleSpecies Specificity
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.