Evidence map›Paper›PMID 38848266›Full record

ArticleACS infectious diseases2024

Strategic Single-Residue Substitution in the Antimicrobial Peptide Esc(1-21) Confers Activity against

Maria Rosa Loffredo, Bruno Casciaro, Rosa Bellavita, Cassandra Troiano, Diego Brancaccio, Floriana Cappiello, Francesco Merlino, Stefania Galdiero, Giancarlo Fabrizi, Paolo Grieco and 3 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Modulating Antimicrobial Activity and Structure of the Peptide Esc(1-21) via Site-Specific Isopeptide Bond Formation.Journal of peptide science : an official publication of the European Peptide Society · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maria Rosa LoffredoDepartment of Biochemical Sciences, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, 00185 Rome, Italy.
Bruno CasciaroDepartment of Biochemical Sciences, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, 00185 Rome, Italy.
Rosa BellavitaDepartment of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0003-2163-5163
Cassandra TroianoDepartment of Chemical Science and Technologies, University of Rome Tor Vergata, 00133 Rome, Italy.
Diego BrancaccioDepartment of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.
Floriana CappielloDepartment of Biochemical Sciences, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, 00185 Rome, Italy.
Francesco MerlinoDepartment of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0002-9607-229X
Stefania GaldieroDepartment of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0002-7849-7024
Giancarlo FabriziDepartment of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, 00185 Rome, Italy.
Paolo GriecoDepartment of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.
Lorenzo StellaDepartment of Chemical Science and Technologies, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-5489-7381
Alfonso CarotenutoDepartment of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0001-7532-5449
Maria Luisa MangoniDepartment of Biochemical Sciences, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-5991-5868

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amino Acid SubstitutionAnti-Bacterial AgentsBiofilmsMicrobial Sensitivity TestsStaphylococcus aureusAmphibian ProteinsAnimalsAntimicrobial Cationic PeptidesAntimicrobial PeptidesDrug Resistance, BacterialHumansAmphibian ProteinsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial Peptidesantimicrobial peptidesbent helical structurebiofilmmultidrug-resistant strainsStaphylococcus aureusα-aminoisobutyric acid

Identifiers

PMID38848266
PMCPMC11250030

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.