Observational studyInvestigative ophthalmology & visual science2024
Associations Between Visual Functions and Severity Gradings, Corneal Scatter, or Higher-Order Aberrations in Fuchs Endothelial Corneal Dystrophy.
Observational study in Investigative ophthalmology & visual science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Determinants of posterior corneal optical densitometry and their relationship with endothelial morphology.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Structural correlates of multidimensional visual dysfunction in Fuchs endothelial corneal dystrophy.Japanese journal of ophthalmology · 2026Article
- Association between subjective symptoms and severity in patients with Fuchs endothelial corneal dystrophy.Japanese journal of ophthalmology · 2026Observational
- Comparative analysis of higher-order aberration profiles in macular and granular corneal dystrophies.International ophthalmology · 2026Article
- Validation and extension of the SUCCESS score for Fuchs dystrophy after cataract surgery.Eye and vision (London, England) · 2026Article
- Risk factors for postoperative endothelial keratoplasty after cataract surgery in patients with Fuchs endothelial corneal dystrophy using anterior segment optical coherence tomography.Japanese journal of ophthalmology · 2026Observational
- Validation of Automated Software for Guttae Quantification in Fuchs Endothelial Corneal Dystrophy.Translational vision science & technology · 2026Article
- Corneal backscatter as a biomarker for edema severity in Fuchs endothelial corneal dystrophy: a cross-sectional study.Eye and vision (London, England) · 2026Article
- Correlation between visual function and corneal backscatter by Scheimpflug imaging or anterior segment optical coherence tomography in Fuchs endothelial corneal dystrophy.Japanese journal of ophthalmology · 2025Article
- Descemet membrane endothelial keratoplasty after cataract surgery with presbyopia-correcting intraocular lens for coexisting Fuchs endothelial corneal dystrophy and cataract.Japanese journal of ophthalmology · 2025Article
- Feasibility and Postoperative Outcome After Duet Procedure for Reversible Multifocality in Eyes with Co-Pathologies.Journal of clinical medicine · 2025Article
- Repeat Expansion and Somatic Instability in TCF4 in Patients With Fuchs Endothelial Corneal Dystrophy Identified by Small Pool PCR.Investigative ophthalmology & visual science · 2025Article
- Validation of the Italian Version of the Visual Function and Corneal Health Status (V-FUCHS) Questionnaire: A Patient-Reported Visual Disability Instrument for Fuchs' Endothelial Corneal Dystrophy.Journal of clinical medicine · 2025Article
- Evaluating Corneal Optical Density and Subbasal Nerve Fiber Metrics in Myopic Patients.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Vision and Quality of Life in Fuchs' Endothelial Dystrophy Using a Prototype Aberrometer: A Cross-Sectional Study.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Assessment of Early Fuchs Endothelial Corneal Dystrophy and CTG Trinucleotide Expansion Positivity Using Scheimpflug Imaging.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The purpose of this study was to investigate the associations between visual function and severity grading, corneal scatter, or higher-order aberrations (HOAs) in patients with Fuchs endothelial corneal dystrophy (FECD). Methods: This observational case series study included 49 eyes of 27 patients with FECD and 10 eyes of 10 healthy individuals. We evaluated corrected distance visual acuity (CDVA) using Landolt-C and Early Treatment Diabetic Retinopathy Study charts and contrast sensitivity using the CSV-1000E chart and CSV-1000RN letter chart. We analyzed the associations between visual function and explanatory variables, including age, modified Krachmer grade, central corneal thickness (CCT), anterior segment optical coherence tomography (AS-OCT)-based grade, HOAs, intraocular straylight, and corneal densitometry. We additionally conducted receiver operating characteristic (ROC) analysis to identify the corneal densitometry thresholds for decreased visual function. Results: There were significant associations between visual function and the modified Krachmer grade, CCT, AS-OCT-based grade, HOAs, intraocular straylight, and corneal densitometry. A modified Krachmer grade ≥ 3 was identified as a threshold for decreased visual function. Multivariate analysis showed that corneal densitometry was significantly associated with all visual function parameters, and HOAs were significantly associated with CDVA but not with contrast sensitivity. ROC analysis revealed that corneal densitometry of the posterior layer at 0 to 2 mm ≥ 10 grayscale units (GSU), was identified as a threshold for decreased visual function. Conclusions: HOAs, forward and backward light scatter affected visual function, with backward light scatter being the most influential. In patients with FECD, modified Krachmer grade ≥ 3 and corneal densitometry ≥ 10 GSU were thresholds for visual disturbance.
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