Evidence map›Paper›PMID 38847924›Full record

ArticleFolia microbiologica2025

The CssRS two-component system of Bacillus subtilis contributes to teicoplanin and polymyxin B response.

Alexandr V Kachan, Anatoly N Evtushenkov

Abstract read
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In one paragraph

Article in Folia microbiologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alexandr V KachanDepartment of Molecular Biology, Faculty of Biology, Belarusian State University, Nezavisimosty Ave., 4, 220030, Minsk, Belarus. alvkachan@gmail.com.ORCID http://orcid.org/0000-0001-9960-4274
Anatoly N EvtushenkovDepartment of Molecular Biology, Faculty of Biology, Belarusian State University, Nezavisimosty Ave., 4, 220030, Minsk, Belarus.ORCID http://orcid.org/0000-0002-2755-6979

Funding

Belarusian Republican Foundation for Fundamental Research B22UZB-035
6 · The paper itself

Abstract

CssRS is a two-component system that plays a pivotal role in mediating the secretion stress response in Bacillus subtilis. This system upregulates the synthesis of membrane-bound HtrA family proteases that cope with misfolded proteins that accumulate within the cell envelope as a result of overexpression or heat shock. Recent studies have shown the induction of CssRS-regulated genes in response to cell envelope stress. We investigated the induction of the CssRS-regulated htrA promoter in the presence of different cell wall- and membrane-active substances and observed induction of the CssRS-controlled genes by glycopeptides (vancomycin and teicoplanin), polymyxins B and E, certain β-lactams, and detergents. Teicoplanin was shown to elicit remarkably stronger induction than vancomycin and polymyxin B. Teicoplanin and polymyxin B induced the spxO gene expression in a CssRS-dependent fashion, resulting in increased activity of Spx, a master regulator of disulfide stress in Bacillus subtilis. The CssRS signaling pathway and Spx activity were demonstrated to be involved in Bacillus subtilis resistance to teicoplanin and polymyxin B.

Indexed as

Anti-Bacterial AgentsBacillus subtilisBacterial ProteinsPolymyxin BTeicoplaninGene Expression Regulation, BacterialPromoter Regions, GeneticSignal TransductionAnti-Bacterial AgentsBacterial ProteinsPolymyxin BTeicoplaninBacillus subtilisCell envelope stressPolymyxin BTeicoplaninTwo-component systemVancomycin

Identifiers

PMID38847924

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.