Evidence map›Paper›PMID 38847919›Full record

ArticlePituitary2024

Utility of copeptin in predicting non-pathological postoperative polyuria in patients affected by acromegaly undergoing pituitary neurosurgery.

Emanuele Varaldo, Nunzia Prencipe, Alessandro Maria Berton, Luigi Simone Aversa, Fabio Bioletto, Raffaele De Marco, Valentina Gasco, Francesco Zenga, Silvia Grottoli

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pituitary, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Emanuele Varaldo *Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, 10126, Italy. emanuele.varaldo@unito.it.ORCID https://orcid.org/0000-0002-3772-8586
Nunzia Prencipe *Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, 10126, Italy.
Alessandro Maria BertonDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, 10126, Italy.
Luigi Simone AversaDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, 10126, Italy.
Fabio BiolettoDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, 10126, Italy.
Raffaele De MarcoSkull Base and Pituitary Surgery Unit, "Città della Salute e della Scienza" University Hospital, Turin, 10126, Italy.
Valentina GascoDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, 10126, Italy.
Francesco ZengaSkull Base and Pituitary Surgery Unit, "Città della Salute e della Scienza" University Hospital, Turin, 10126, Italy.
Silvia GrottoliDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, 10126, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCopeptin efficiently predicts post-neurosurgical central diabetes insipidus (CDI) in patients with hypothalamic-pituitary lesions, but its role in characterizing changes in diuresis in individuals with acromegaly undergoing neurosurgery remains unexplored. Our study aimed to assess changes in postoperative fluid balance in acromegaly patients and correlate them with both copeptin and growth hormone (GH) levels.

methodsThis was a secondary analysis of a prospective study involving 15 acromegaly patients undergoing endoscopic endonasal resection at our University Hospital. Fluid balance was assessed daily, and copeptin and GH levels were evaluated preoperatively (T0), and serially on the morning of the first (T2) and second (T3) postoperative day, with an additional measurement of copeptin one hour post-extubation (T1). Patients with pre-existing or post-neurosurgical CDI were excluded from the analysis.

resultsMost patients (11/15) exhibited a negative fluid balance on the second postoperative day, with 4 developing polyuria. Postoperative GH levels did not differ significantly between polyuric and non-polyuric patients, but GH measured at T2 correlated significantly with negative total balance (r = -0.519, p = 0.048). Copeptin levels at T1 were significantly higher in those who developed polyuria (p = 0.013), and a copeptin value > 39.9 pmol/L at T1 showed excellent ability (Sensitivity 100%, Specificity 90.9%, p < 0.001) in predicting postoperative polyuria. Additionally, polyuric patients exhibited a higher T1 / T3 copeptin ratio (p = 0.013) and a negative fluid balance was associated with the remission of acromegaly at 12 months (p = 0.046).

conclusionThe early assessment of copeptin, in addition to facilitating the rapid identification of individuals at increased risk of developing CDI, could also allow the recognition of subjects with a tendency towards non-pathological polyuria in the postoperative setting, at least in individuals affected by acromegaly.

Indexed as

AcromegalyGlycopeptidesPolyuriaAdultAgedDiabetes Insipidus, NeurogenicFemaleHumansMaleMiddle AgedNeurosurgical ProceduresPituitary GlandPostoperative ComplicationsProspective StudiescopeptinsGlycopeptidesArginine vasopressinCentral diabetes insipidusCT-proAVPFluid balanceGHGrowth hormone

Identifiers

PMID38847919
PMCPMC11513703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.