Evidence map›Paper›PMID 38847888›Full record

ArticleBioprocess and biosystems engineering2024

Process optimized for production of iturin A in biofilm reactor by Bacillus velezensis ND.

Zhongmin Tang, Leiming Wang, Zhengjun Xiong, Yuxia Zhu, Huili Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Bioprocess and biosystems engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Antimicrobial Activity ofInternational journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhongmin Tang *College of Life Sciences, Shihezi University, Xinjiang, People's Republic of China.ORCID http://orcid.org/0000-0003-3977-6167
Leiming Wang *College of Life Sciences, Shihezi University, Xinjiang, People's Republic of China.
Zhengjun XiongSel Biochem Xinjiang Co., Ltd, Xinjiang, People's Republic of China.
Yuxia ZhuSel Biochem Xinjiang Co., Ltd, Xinjiang, People's Republic of China.
Huili ZhangCollege of Life Sciences, Shihezi University, Xinjiang, People's Republic of China. tzm1662111694@163.com.

Funding

Data Center of Management Science, National Natural Science Foundation of China - Peking University 21366028
6 · The paper itself

Abstract

In this research, to provide an optimal growth medium for the production of iturin A, the concentrations of key amino acid precursors were optimized in shake flask cultures using the response surface method. The optimized medium were applied in a biofilm reactor for batch fermentation, resulting in enhanced production of iturin A. On this basis, a step-wise pH control strategy and a combined step-wise pH and temperature control strategy were introduced to further improve the production of iturin A. Finally, the fed-batch fermentation was performed based on combined step-wise pH and temperature control. The titer and productivity of iturin A reached 7.86 ± 0.23 g/L and 65.50 ± 1.92 mg/L/h, respectively, which were 37.65 and 65.20% higher than that before process optimization.

Indexed as

BacillusBiofilmsBioreactorsCulture MediaFermentationHydrogen-Ion ConcentrationPeptides, CyclicTemperatureCulture Mediaiturin APeptides, CyclicAmino acidsBiofilm reactorFermentation optimizationIturin A

Identifiers

PMID38847888

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.