Evidence map›Paper›PMID 38847871›Full record

SynthesisPediatric surgery international2024

Utility of thiol/disulphide homeostasis as a biomarker for acute appendicitis: a systematic review and meta-analysis.

Nellai Krishnan, Niklas Pakkasjärvi, Deepika Kainth, Javier Arredondo Montero, Johan Danielson, Pulkit Verma, Ajay Verma, Devendra Kumar Yadav, Sachit Anand

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Pediatric surgery international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Nellai Krishnan *Department of Pediatric Surgery, All India Institute of Medical Sciences, Ansari Nagar East, New Delhi, 110029, Delhi, India.
Niklas Pakkasjärvi *Department of Pediatric Surgery, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland.
Deepika KainthDivision of Neonatology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Javier Arredondo MonteroPediatric Surgery Department, Complejo Asistencial Universitario de León, León, Spain.
Johan DanielsonDepartment of Pediatric Surgery, Section of Urology, University Children's Hospital, Uppsala, Sweden.
Pulkit VermaDivision of Biomedical Informatics, Indian Council of Medical Research, New Delhi, India.
Ajay VermaDepartment of Pediatric Surgery, All India Institute of Medical Sciences, Ansari Nagar East, New Delhi, 110029, Delhi, India.
Devendra Kumar YadavDepartment of Pediatric Surgery, All India Institute of Medical Sciences, Ansari Nagar East, New Delhi, 110029, Delhi, India.
Sachit AnandDepartment of Pediatric Surgery, All India Institute of Medical Sciences, Ansari Nagar East, New Delhi, 110029, Delhi, India. kanu.sachit@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to analyze the role of thiol/disulfide homeostasis (TDH) parameters as an indicator of oxidative stress in acute appendicitis (AA). PubMed, EMBASE, Web of Science, and Scopus databases were systematically searched. Studies reporting on TDH in AA (both complicated and uncomplicated cases) were included. The comparator group were healthy controls. The TDH domain was compared between the groups using anti-oxidant parameters, namely native thiol and total thiol levels, and native thiol/total thiol ratio; and oxidant parameters, namely disulfide level, disulfide/native thiol ratio, and disulfide/total thiol ratio. The statistical analysis was performed using a random-effects model. The methodological quality of the studies was assessed utilizing the Newcastle-Ottawa scale. Eleven studies with a total of 926 subjects, comprising 457 patients with uncomplicated appendicitis, 147 with complicated appendicitis, and 322 healthy controls were included. Our study demonstrated significantly increased oxidative stress in AA as compared to healthy controls in all TDH parameters and significantly lower total thiol levels in complicated AA as compared to uncomplicated AA. Due to a poor methodological quality in five out of eleven studies, future prospective studies with adequate power are essential to validate these observations and refine the diagnostic approaches to AA.

Indexed as

AppendicitisBiomarkersDisulfidesHomeostasisOxidative StressSulfhydryl CompoundsAcute DiseaseHumansBiomarkersDisulfidesSulfhydryl CompoundsAcute appendicitisBiomarkerOxidative stressThiol–disulfide homeostasisThiol levels

Identifiers

PMID38847871

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.