Evidence map›Paper›PMID 38847758›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2024

Kaelin A Akins, Michael A Flinn, Samantha K Swift, Smrithi V Chanjeevaram, Alexandra L Purdy, Tyler Buddell, Mary E Kolell, Kaitlyn G Andresen, Samantha Paddock, Sydney L Buday and 3 more

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Growth under pressure: The pros and cons of polyploidy induced by stress.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kaelin A AkinsDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Michael A FlinnCardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-8200-1693
Samantha K SwiftDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Smrithi V ChanjeevaramDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Alexandra L PurdyDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Tyler BuddellDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Mary E KolellDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Kaitlyn G AndresenDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Samantha PaddockDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Sydney L BudayDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Matthew B VeldmanDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Caitlin C O'MearaCardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-9212-0821
Michaela PattersonDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-3805-4181

Funding

INTEGRATED PHYSIOLOGY TRAINING--MOLECULE TO ORGANISMT32HL007852 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Matthew Robert Hodges · 1996 to 2026
$6.5M
Training in Signature Transdisciplinary Cardiovascular SciencesT32HL134643 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Justin L Grobe, Jacquelyn P Kulinski · 2017 to 2026
$4.2M
Genetic interactions and multifactorial genetics mediate myocardial regenerationR01HL155085 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI PATTERSON, MICHAELA · 2021 to 2025
$2.5M
IL13 - A Novel Therapeutic Factor for Cardiac RegenerationR01HL141159 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI O'MEARA, CAITLIN C · 2019 to 2023
$2.1M
Modulators of cardiomyocyte structure to promote functional recovery during cardiac regeneration and repairR01HL170547 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Brian A Link, Caitlin C O'Meara · 2023 to 2026
$2.1M
Genetic mapping of variable cardiac cell composition in the ratR21HL156022 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI O'MEARA, CAITLIN C, PATTERSON, MICHAELA · 2021 to 2022
$443k
VisualSonics Vevo 3100 High-Frequency Ultrasound Imaging SystemS10OD025038 · OD · MEDICAL COLLEGE OF WISCONSIN · PI AUCHAMPACH, JOHN A · 2019 to 2019
$302k
The fibrogenic role of Hippo-Yap signaling following ischemic injuryF32HL150958 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI FLINN, MICHAEL A · 2020 to 2023
$161k
The Role of Runx1 in Cardiomyocyte Cell Cycle and PloidyF31HL162468 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI SWIFT, SAMANTHA K · 2022 to 2023
$91k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F31HL162468HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F32HL150958HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL141159HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL155085HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL155085-S1HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL170547HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) T32HL007852HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) T32HL034643HHS | NIH | NIH Office of the Director (OD) S10OD025038NHLBI NIH HHS F31 HL162468NHLBI NIH HHS F32 HL150958NHLBI NIH HHS R01 HL141159NHLBI NIH HHS R01 HL155085NHLBI NIH HHS R01 HL170547NHLBI NIH HHS R21 HL156022NHLBI NIH HHS T32 HL007852NHLBI NIH HHS T32 HL134643NIH HHS S10 OD025038
6 · The paper itself

Abstract

Factors responsible for cardiomyocyte proliferation could serve as potential therapeutics to stimulate endogenous myocardial regeneration following insult, such as ischemic injury. A previously published forward genetics approach on cardiomyocyte cell cycle and ploidy led us to the transcription factor,

Indexed as

Cell CycleCell ProliferationCore Binding Factor Alpha 2 SubunitMyocytes, CardiacAnimalsAnimals, NewbornMiceMice, Inbred C57BLPolyploidyRegenerationCore Binding Factor Alpha 2 SubunitRunx1 protein, mousecardiomyocyteendomitosisploidyproliferationRunx1

Identifiers

PMID38847758
PMCPMC11442100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.