Evidence map›Paper›PMID 38847615›Full record

ArticleRadiology. Imaging cancer2024

Molecular Breast Imaging Biopsy with a Dual-Detector System.

Katie N Hunt, Amy Lynn Conners, Lacey Gray, Carrie B Hruska, Michael K O'Connor

Abstract read
In one paragraph

Article in Radiology. Imaging cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Current and future perspectives of molecular breast imaging with [European journal of nuclear medicine and molecular imaging · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Current Concepts in Molecular Breast Imaging.Journal of breast imaging · 2025
    Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Katie N HuntFrom the Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.ORCID 0000-0003-2889-3528
Amy Lynn ConnersFrom the Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Lacey GrayFrom the Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Carrie B HruskaFrom the Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.ORCID 0000-0002-6195-5201
Michael K O'ConnorFrom the Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.ORCID 0000-0002-2816-1928

Funding

Density MATTERS Clinical TrialR01CA239200 · NCI · MAYO CLINIC ROCHESTER · PI HRUSKA, CARRIE B, RHODES, DEBORAH · 2020 to 2024
$3.2M
NCI NIH HHS R01 CA239200
6 · The paper itself

Abstract

Purpose To develop a molecular breast imaging (MBI)-guided biopsy system using dual-detector MBI and to perform initial testing in participants. Materials and Methods The Stereo Navigator MBI Accessory biopsy system comprises a lower detector, upper fenestrated compression paddle, and upper detector. The upper detector retracts, allowing craniocaudal, oblique, or medial or lateral biopsy approaches. The compression paddle allows insertion of a needle guide and needle. Lesion depth is calculated by triangulation of lesion location on the upper detector at 0° and 15° and relative lesion activity on upper and lower detectors. In a prospective study (July 2022-June 2023), participants with Breast Imaging Reporting and Data System category 2, 3, 4, or 5 breast lesions underwent MBI-guided biopsy. After injection of 740 MBq technetium 99m sestamibi, craniocaudal and mediolateral oblique MBI (2-minute acquisition per view) confirmed lesion visualization. A region of interest over the lesion permitted depth calculation in the system software. Upper detector retraction allowed biopsy device placement. Specimen images were obtained on the retracted upper detector, confirming sampling of the target. Results Of 21 participants enrolled (mean age, 50.6 years ± 10.1 [SD]; 21 [100%] women), 17 underwent MBI-guided biopsy with concordant pathology. No lesion was observed at the time of biopsy in four participants. Average lesion size was 17 mm (range, 6-38 mm). Average procedure time, including preprocedure imaging, was 55 minutes ± 13 (range, 38-90 minutes). Pathology results included invasive ductal carcinoma (

Indexed as

Breast NeoplasmsImage-Guided BiopsyMolecular ImagingTechnetium Tc 99m SestamibiAdultAgedBreastFemaleHumansMiddle AgedProspective StudiesRadiopharmaceuticalsRadiopharmaceuticalsTechnetium Tc 99m SestamibiBreast BiopsyBreast CancerImage-guided BiopsyMolecular Breast ImagingMolecular Breast Imaging–guided Biopsy

Identifiers

PMID38847615
PMCPMC11287224

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.