Evidence map›Paper›PMID 38847587›Full record

ArticleFaraday discussions2024

An efficient pyrrolysyl-tRNA synthetase for economical production of MeHis-containing enzymes.

Amy E Hutton, Jake Foster, James E J Sanders, Christopher J Taylor, Stefan A Hoffmann, Yizhi Cai, Sarah L Lovelock, Anthony P Green

Abstract read
In one paragraph

Article in Faraday discussions, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Catalytic pBiochemistry · 2026
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amy E HuttonManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Manchester, UK. Anthony.green@manchester.ac.uk.ORCID 0000-0003-1324-6627
Jake FosterManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Manchester, UK. Anthony.green@manchester.ac.uk.
James E J SandersManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Manchester, UK. Anthony.green@manchester.ac.uk.
Christopher J TaylorManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Manchester, UK. Anthony.green@manchester.ac.uk.
Stefan A HoffmannManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Manchester, UK. Anthony.green@manchester.ac.uk.ORCID 0000-0002-3184-8640
Yizhi CaiManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Manchester, UK. Anthony.green@manchester.ac.uk.
Sarah L LovelockManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Manchester, UK. Anthony.green@manchester.ac.uk.ORCID 0000-0002-4584-3189
Anthony P GreenManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Manchester, UK. Anthony.green@manchester.ac.uk.ORCID 0000-0003-0454-1798

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic code expansion has emerged as a powerful tool in enzyme design and engineering, providing new insights into sophisticated catalytic mechanisms and enabling the development of enzymes with new catalytic functions. In this regard, the non-canonical histidine analogue

Indexed as

Amino Acyl-tRNA SynthetasesCatalytic DomainHistidineLysineMethylhistidinesAmino Acyl-tRNA SynthetasesHistidineLysineMethylhistidinespyrrolysine

Identifiers

PMID38847587
PMCPMC11389853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.