ArticleThe Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association2025
Barriers to participation in clinical trials of rural older adult cancer survivors: A qualitative study.
Article in The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- How Can We Reach You? An Overview of Establishing Effective Recruitment Strategies for Young Women Breast Cancer Survivors.Cancer care research online · 2026Article
- Cancer clinical trial recruitment for patients from rural areas: a scoping review.International journal for equity in health · 2026Article
- Closing the gap of older adult recruitment to cancer clinical trials: a scoping review.BMC cancer · 2026Article
- Reporting and representation of race and ethnicity data in phase III clinical trials for hematological malignancies.Future science OA · 2025Article
- 'The seagull theory: Where people fly in, gather information… fly out and nothing ever comes about': A qualitative exploration of barriers and enablers to research participation among adults with type 2 diabetes living in Australian rural communities.Diabetic medicine : a journal of the British Diabetic Association · 2025Article
- Barriers to participation in clinical trials of rural older adult cancer survivors: A qualitative study.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2025Article
- Signals for change: A regional examination of rural clinical trial participant perspectives on values, health behaviors, and motivations for enrollment and retention in remote settings.Journal of clinical and translational science · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundCurrently, 64% of cancer survivors are aged 65+. Older cancer survivors have unique complications after chemotherapy and are often excluded from cancer clinical trials. Although there is research on barriers to clinical trial participation of older adult cancer survivors, to date no research has explored barriers to clinical trial participation unique to rural older adult cancer survivors.
methodsThis study is a secondary qualitative analysis from a study exploring survivorship challenges of rural older adults. Eligible participants were rural residents over age 65 who have completed curative-intent chemotherapy in the past 12 months. Participants (n = 27) completed open-ended semi-structured interviews that included questions on barriers to clinical trial participation. Transcripts were coded independently by two coders using thematic analysis. We have adhered to the standards for reporting qualitative research.
findingsParticipants reported a variety of barriers that included limited knowledge and fear about clinical trials, transportation challenges, their physicians not informing them of clinical trials, and thinking they are too old to participate in clinical trials. However, participants also reported facilitators to participating in clinical trials, including acknowledging benefits to their own health and society, and understanding the importance of clinical trials.
conclusionRural older cancer survivors face numerous interpersonal, intrapersonal, and organizational barriers to clinical trial participation. Aging- and location-sensitive interventions that focus on patients, their caregivers, and health care providers may lead to improved participation of rural older adult survivors into clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.