Evidence map›Paper›PMID 38847259›Full record

ArticleMedicinal chemistry (Shariqah (United Arab Emirates))2024

Wallyson André Dos Santos Bezerra, Caio Pavão Tavares, Victor Antônio Silva Lima, Cláudia Quintino da Rocha, Itabajara da Silva Vaz Junior, Paul A M Michels, Livio Martins Costa Junior, Alexandra Martins Dos Santos Soares

Abstract read
PubMed Publisher
In one paragraph

Article in Medicinal chemistry (Shariqah (United Arab Emirates)), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wallyson André Dos Santos BezerraPrograma de Pós-Graduação em Biodiversidade e Biotecnologia da Amazônia - Bionorte, Universidade Federal do Maranhão, São Luís, MA, Brazil.ORCID 0000-0002-9151-9654
Caio Pavão TavaresLaboratório de Controle de Parasitos, Departamento de Patologia, Universidade Federal do Maranhão, São Luís, MA, Brazil.
Victor Antônio Silva LimaLaboratório de Química de Produtos Naturais, Departamento de Química, Universidade Federal do Maranhão, São Luís, MA, Brazil.
Cláudia Quintino da RochaLaboratório de Química de Produtos Naturais, Departamento de Química, Universidade Federal do Maranhão, São Luís, MA, Brazil.
Itabajara da Silva Vaz JuniorFaculdade de Veterinária, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Paul A M MichelsSchool of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom.
Livio Martins Costa JuniorLaboratório de Química de Produtos Naturais, Departamento de Química, Universidade Federal do Maranhão, São Luís, MA, Brazil.
Alexandra Martins Dos Santos SoaresPrograma de Pós-Graduação em Biodiversidade e Biotecnologia da Amazônia - Bionorte, Universidade Federal do Maranhão, São Luís, MA, Brazil.ORCID 0000-0003-1077-5064

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001,,Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão 00869/22,03170/18
6 · The paper itself

Abstract

introduction

methodsTo address this challenge, innovative solutions targeting essential tick enzymes, like glutathione S-transferase (GST), have gained attention. Dimeric flavonoids, particularly brachydins (BRAs), have demonstrated various biological activities, including antiparasitic effects. The objectives of this study were to isolate four dimeric flavonoids from

results

conclusionThe findings of this study deepen our understanding of GST inhibition in ticks, affirming its viability as a drug target. This knowledge contributes to the advancement of treatment modalities and strategies for improved tick control.

Indexed as

FlavonoidsGlutathione TransferaseMolecular Docking SimulationRhipicephalusAnimalsComputer SimulationDimerizationEnzyme InhibitorsEnzyme InhibitorsFlavonoidsGlutathione Transferasedimeric flavonoidsFridericia platyphyllaGST inhibitionRhipicephalus microplus.Tick

Identifiers

PMID38847259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.