Evidence map›Paper›PMID 38846999›Full record

ArticleMolecular therapy. Nucleic acids2024

Aberrant spliceosome activity via elevated intron retention and upregulation and phosphorylation of SF3B1 in chronic lymphocytic leukemia.

Manoj Kumar Kashyap, Hiren Karathia, Deepak Kumar, Roberto Vera Alvarez, Jose Vicente Forero-Forero, Eider Moreno, Juliana Velez Lujan, Carlos Ivan Amaya-Chanaga, Newton Medeiros Vidal, Zhe Yu and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Manoj Kumar KashyapMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820, USA.
Hiren KarathiaAdvanced Biomedical Computational Science and National Center for Advancing Translational Sciences, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.
Deepak KumarMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820, USA.
Roberto Vera AlvarezNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Jose Vicente Forero-ForeroDepartment of Internal Medicine, Division of Hematology-Oncology, Mayo Clinic, Phoenix, AZ 85054, USA.
Eider MorenoDepartment of Internal Medicine, Division of Hematology-Oncology, Mayo Clinic, Phoenix, AZ 85054, USA.
Juliana Velez LujanMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820, USA.
Carlos Ivan Amaya-ChanagaMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820, USA.
Newton Medeiros VidalNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Zhe YuMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820, USA.
Emanuela M GhiaMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820, USA.
Paula A Lengerke-DiazDepartment of Internal Medicine, Division of Hematology-Oncology, Mayo Clinic, Phoenix, AZ 85054, USA.
Daniel AchinkoNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Michael Y ChoiMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820, USA.
Laura Z RassentiMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820, USA.
Leonardo Mariño-RamírezNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Stephen M MountDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA.
Sridhar HannenhalliCancer Data Science Lab, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Thomas J KippsMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820, USA.
Januario E CastroMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820, USA.

Funding

Genomics and Biobank Research for Health EquityZIAMD000018 · NIMHD · NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES · PI MARIÑO-RAMÍREZ, LEONARDO · 2020 to 2025
$2.7M
Transcriptional heterogeneity and regulatory mechanisms in tumor microenvironmentZIABC012176 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HANNENHALLI, SRIDHAR · 2024 to 2025
$1.3M
6 · The paper itself

Abstract

Splicing factor 3b subunit 1 (SF3B1) is the largest subunit and core component of the spliceosome. Inhibition of SF3B1 was associated with an increase in broad intron retention (IR) on most transcripts, suggesting that IR can be used as a marker of spliceosome inhibition in chronic lymphocytic leukemia (CLL) cells. Furthermore, we separately analyzed exonic and intronic mapped reads on annotated RNA-sequencing transcripts obtained from B cells (

Indexed as

alternative RNA splicingCLLE7107intron retentionintron usagemacrolideMT: RNA/DNA Editingpladienolide-BRNA-seqRNA splicingSF3B1spliceosome

Identifiers

PMID38846999
PMCPMC11154714

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.