ArticleFrontiers in oncology2024
Case report: Isolated immunoglobulin G4-related sclerosing cholangitis misdiagnosed as hilar cholangiocarcinoma.
Article in Frontiers in oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- IgG4-related autoimmune pancreatitis mimicking pancreatic carcinoma: a case report.Frontiers in medicine · 2026Article
- IgG4-related Sclerosing Cholangitis Masquerading as Cholangiocarcinoma: A Diagnostic Challenge.Journal of community hospital internal medicine perspectives · 2026Article
- Isolated IgG4-related sclerosing cholangitis mimicking hilar cholangiocarcinoma: A case report and review.Hepatology forum · 2025Article
- Sump syndrome following hepaticojejunostomy: a case report of IgG4-related sclerosing cholangitis.Frontiers in medicine · 2025Article
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7 authors.
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Abstract
Background: Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) is frequently accompanied with type 1 autoimmune pancreatitis (AIP). Isolated IgG4-SC which is not accompanied with AIP is uncommon in clinical practice, and its manifestations are similar to those of hilar cholangiocarcinoma. Case presentation: A 55-year-old male presented with persistent aggravation of icteric sclera and skin. He was initially diagnosed with hilar cholangiocarcinoma and underwent surgery. However, positive IgG4 plasma cells were found in the surgical specimens. Thus, a pathological diagnosis of IgG4-SC was established. After that, steroid therapy was given and initially effective. But he was steroid dependent, and then received rituximab therapy twice. Unfortunately, the response to rituximab therapy was poor. Conclusion: It is crucial to differentiate isolated IgG4-SC from hilar cholangiocarcinoma to avoid unnecessary surgery. Future studies should further explore effective treatment strategy in patients who do not respond to steroids therapy. It is also required to develop novel and accurate diagnostic approaches to avoid unnecessary surgical procedures.
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