Evidence map›Paper›PMID 38846956›Full record

ArticleFrontiers in immunology2024

Macrophage-derived macrophage migration inhibitory factor mediates renal injury in anti-glomerular basement membrane glomerulonephritis.

Hui Yang, Jinhong Li, Xiao-Ru Huang, Richard Bucala, Anping Xu, Hui-Yao Lan

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hui Yang *Department of Nephrology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Jinhong Li *Department of Nephrology, The Seventh Affiliated Hospital of Sun Yat-sen University, SunYat-sen University, Shenzhen, China.
Xiao-Ru HuangDepartment of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Richard BucalaDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States.
Anping XuDepartment of Nephrology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Hui-Yao LanDepartment of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.

Funding

Defining the Pathogenic Contribution of High Genotypic MIF ExpressionR01AR078334 · NIAMS · YALE UNIVERSITY · PI BUCALA, RICHARD J · 2021 to 2025
$1.8M
NIAMS NIH HHS R01 AR078334
6 · The paper itself

Abstract

Macrophages are a rich source of macrophage migration inhibitory factor (MIF). It is well established that macrophages and MIF play a pathogenic role in anti-glomerular basement membrane crescentic glomerulonephritis (anti-GBM CGN). However, whether macrophages mediate anti-GBM CGN via MIF-dependent mechanism remains unexplored, which was investigated in this study by specifically deleting MIF from macrophages in MIF

Indexed as

Antigens, Differentiation, B-LymphocyteAnti-Glomerular Basement Membrane DiseaseIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMacrophagesAnimalsDisease Models, AnimalHistocompatibility Antigens Class IIMiceMice, Inbred C57BLMice, KnockoutNF-kappa Bp38 Mitogen-Activated Protein KinasesProteinuriaSignal TransductionTh17 CellsAntigens, Differentiation, B-LymphocyteHistocompatibility Antigens Class IIIntramolecular Oxidoreductasesinvariant chainMacrophage Migration-Inhibitory FactorsMif protein, mouseNF-kappa Bp38 Mitogen-Activated Protein Kinasesanti-GBM crescentic glomerulonephritisinflammationmacrophagesMIFT cells

Identifiers

PMID38846956
PMCPMC11153660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.